FAAH2
Gene Information
- Official Symbol: FAAH2
- Official Name: fatty acid amide hydrolase 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 158584
- UniProt: Q6GMR7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a fatty acid amide hydrolase that shares a conserved protein motif with the amidase signature family of enzymes. The encoded enzyme is able to catalyze the hydrolysis of a broad range of bioactive lipids, including those from the three main classes of fatty acid amides; N-acylethanolamines, fatty acid primary amides and N-acyl amino acids. This enzyme has a preference for monounsaturated acyl chains as a substrate. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017].
- UniProt Summary: Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates. {ECO:0000269|PubMed:17015445}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 18688
- Expression level (log2 read counts): -4.27
FAAH2 Expression in NALM6 Cells: -4.27
