FAT2
Gene Information
- Official Symbol: FAT2
- Official Name: FAT atypical cadherin 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 2196
- UniProt: Q9NYQ8
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene is the second identified human homolog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has two epidermal growth factor (EGF)-like repeats and one laminin G domain. This protein most likely functions as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development. [provided by RefSeq, Jul 2008].
- UniProt Summary: Plays a role in the migration of epidermal cells. May modulate the extracellular space surronding parallel fibers of cerebellar during development (By similarity). {ECO:0000250, ECO:0000269|PubMed:18534823}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 2980
- Expression level (log2 read counts): 0.53
FAT2 Expression in NALM6 Cells: 0.53
