Pfam Domains GO Terms
| FCH |
| SH3 2 |
| SH3 1 |
| cuticular plate |
| multi-organism membrane organization |
| multi-organism cellular process |
| neuromuscular synaptic transmission |
| neuromuscular junction |
| positive regulation of actin filament polymerization |
| cell projection |
| recycling endosome |
| positive regulation of protein polymerization |
| perikaryon |
| lipid binding |
| regulation of actin filament polymerization |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| positive regulation of supramolecular fiber organization |
| positive regulation of cytoskeleton organization |
| regulation of protein polymerization |
| positive regulation of protein complex assembly |
| regulation of actin filament organization |
| regulation of actin cytoskeleton organization |
| regulation of supramolecular fiber organization |
| regulation of cellular component size |
| regulation of actin filament-based process |
| anterograde trans-synaptic signaling |
| chemical synaptic transmission |
| trans-synaptic signaling |
| regulation of protein complex assembly |
| synaptic signaling |
| regulation of anatomical structure size |
| positive regulation of cellular component biogenesis |
| regulation of cytoskeleton organization |
| positive regulation of organelle organization |
| membrane organization |
| regulation of cellular component biogenesis |
| cell-cell signaling |
| positive regulation of cellular component organization |
| regulation of organelle organization |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Screen | Score |
|---|---|
| GSK-J4 1μM R07 exp362 | -1.99 |
| Bortezomib 0.005μM R00 exp6 | -1.92 |
| Epothilone-D 0.004 to 0.006μM on day4 R05 exp232 | -1.82 |
| HMS-I2 5μM R06 exp287 | -1.8 |
| BVD-523 15μM R02 exp67 | -1.77 |
| Genistein 15μM R07 exp360 | 2.2 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Expression Distribution