Entrez Summary: The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. This protein localizes to the endoplasmic reticulum and acts as a molecular chaperone. Alternatively spliced variants encoding different isoforms have been reported, but their biological validity has not been determined.[provided by RefSeq, Nov 2009].
UniProt Summary: PPIases accelerate the folding of proteins during protein synthesis.
Pfam DomainsGO Terms
Pfam Domains
FKBP C
GO Terms
FK506 binding
protein peptidyl-prolyl isomerization
peptidyl-prolyl cis-trans isomerase activity
peptidyl-proline modification
endoplasmic reticulum lumen
calcium ion binding
peptidyl-amino acid modification
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739