FKBP1B
Gene Information
- Official Symbol: FKBP1B
- Official Name: FKBP prolyl isomerase 1B
- Aliases and Previous Symbols: N/A
- Entrez ID: 2281
- UniProt: P68106
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Pfam Domains GO Terms
Pfam Domains
| FKBP C |
GO Terms
| cyclic nucleotide binding |
| ryanodine-sensitive calcium-release channel activity |
| positive regulation of axon regeneration |
| protein maturation by protein folding |
| positive regulation of neuron projection regeneration |
| neuronal action potential propagation |
| negative regulation of insulin secretion involved in cellular response to glucose stimulus |
| FK506 binding |
| action potential propagation |
| negative regulation of heart rate |
| negative regulation of ryanodine-sensitive calcium-release channel activity |
| response to vitamin E |
| calcium channel inhibitor activity |
| response to redox state |
| negative regulation of release of sequestered calcium ion into cytosol |
| positive regulation of sequestering of calcium ion |
| cell communication by electrical coupling involved in cardiac conduction |
| negative regulation of calcium ion transport into cytosol |
| cell communication by electrical coupling |
| regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| calcium-mediated signaling using intracellular calcium source |
| calcium channel complex |
| negative regulation of heart contraction |
| regulation of axon regeneration |
| regulation of cardiac muscle contraction by calcium ion signaling |
| regulation of ryanodine-sensitive calcium-release channel activity |
| regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| regulation of neuron projection regeneration |
| negative regulation of calcium-mediated signaling |
| sarcoplasmic reticulum membrane |
| negative regulation of blood circulation |
| negative regulation of calcium ion transmembrane transporter activity |
| protein refolding |
| negative regulation of insulin secretion |
| T cell proliferation |
| negative regulation of calcium ion transmembrane transport |
| insulin secretion |
| de novo protein folding |
| negative regulation of cation channel activity |
| cell communication involved in cardiac conduction |
| negative regulation of peptide hormone secretion |
| protein peptidyl-prolyl isomerization |
| peptidyl-prolyl cis-trans isomerase activity |
| smooth muscle contraction |
| release of sequestered calcium ion into cytosol |
| transmission of nerve impulse |
| regulation of insulin secretion involved in cellular response to glucose stimulus |
| negative regulation of sequestering of calcium ion |
| chaperone-mediated protein folding |
| peptide hormone secretion |
| negative regulation of phosphoprotein phosphatase activity |
| negative regulation of calcium ion transport |
| peptidyl-proline modification |
| negative regulation of hormone secretion |
| positive regulation of response to wounding |
| negative regulation of protein dephosphorylation |
| calcium ion transmembrane import into cytosol |
| regulation of cardiac conduction |
| negative regulation of ion transmembrane transporter activity |
| hormone secretion |
| calcium ion transport into cytosol |
| regulation of cardiac muscle contraction |
| regulation of release of sequestered calcium ion into cytosol |
| negative regulation of transporter activity |
| hormone transport |
| negative regulation of cation transmembrane transport |
| lymphocyte proliferation |
| mononuclear cell proliferation |
| response to vitamin |
| regulation of calcium ion transmembrane transporter activity |
| cytosolic calcium ion transport |
| regulation of striated muscle contraction |
| cardiac conduction |
| action potential |
| negative regulation of ion transmembrane transport |
| regulation of heart rate |
| regulation of calcium-mediated signaling |
| leukocyte proliferation |
| regulation of calcium ion transport into cytosol |
| negative regulation of phosphatase activity |
| negative regulation of dephosphorylation |
| negative regulation of transmembrane transport |
| regulation of phosphoprotein phosphatase activity |
| response to hydrogen peroxide |
| regulation of sequestering of calcium ion |
| ion channel binding |
| negative regulation of protein secretion |
| Z disc |
| multicellular organismal signaling |
| response to glucose |
| negative regulation of peptide secretion |
| regulation of protein dephosphorylation |
| response to hexose |
| calcium-mediated signaling |
| regulation of calcium ion transmembrane transport |
| negative regulation of ion transport |
| response to monosaccharide |
| protein secretion |
| establishment of protein localization to extracellular region |
| regulation of muscle contraction |
| protein localization to extracellular region |
| regulation of response to wounding |
| signal release |
| response to carbohydrate |
| regulation of cation channel activity |
| peptide secretion |
| regulation of phosphatase activity |
| regulation of insulin secretion |
| negative regulation of protein transport |
| negative regulation of establishment of protein localization |
| response to reactive oxygen species |
| calcium ion transmembrane transport |
| negative regulation of secretion by cell |
| regulation of peptide hormone secretion |
| regulation of dephosphorylation |
| response to nutrient |
| protein maturation |
| protein folding |
| negative regulation of secretion |
| T cell activation |
| regulation of muscle system process |
| regulation of heart contraction |
| regulation of calcium ion transport |
| calcium ion transport |
| muscle contraction |
| regulation of ion transmembrane transporter activity |
| regulation of transmembrane transporter activity |
| regulation of hormone secretion |
| regulation of transporter activity |
| positive regulation of neuron projection development |
| positive regulation of cytosolic calcium ion concentration |
| regulation of blood circulation |
| divalent metal ion transport |
| muscle system process |
| divalent inorganic cation transport |
| response to antibiotic |
| regulation of cytosolic calcium ion concentration |
| regulation of cation transmembrane transport |
| signaling receptor binding |
| second-messenger-mediated signaling |
| positive regulation of neuron differentiation |
| positive regulation of cell projection organization |
| lymphocyte activation |
| regulation of metal ion transport |
| response to oxidative stress |
| regulation of membrane potential |
| cellular calcium ion homeostasis |
| calcium ion homeostasis |
| negative regulation of hydrolase activity |
| regulation of protein secretion |
| cellular divalent inorganic cation homeostasis |
| positive regulation of neurogenesis |
| regulation of ion transmembrane transport |
| negative regulation of transport |
| divalent inorganic cation homeostasis |
| regulation of peptide secretion |
| regulation of neuron projection development |
| response to nutrient levels |
| negative regulation of intracellular signal transduction |
| response to toxic substance |
| response to extracellular stimulus |
| regulation of hormone levels |
| response to inorganic substance |
| positive regulation of nervous system development |
| positive regulation of cell development |
| cell population proliferation |
| cellular metal ion homeostasis |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| inorganic cation transmembrane transport |
| regulation of transmembrane transport |
| regulation of system process |
| negative regulation of protein modification process |
| positive regulation of response to external stimulus |
| cation transmembrane transport |
| metal ion homeostasis |
| cellular cation homeostasis |
| metal ion transport |
| cellular ion homeostasis |
| inorganic ion transmembrane transport |
| regulation of neuron differentiation |
| regulation of plasma membrane bounded cell projection organization |
| regulation of ion transport |
| cation homeostasis |
| regulation of protein transport |
| regulation of cell projection organization |
| inorganic ion homeostasis |
| regulation of cellular response to stress |
| regulation of peptide transport |
| cellular chemical homeostasis |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| ion homeostasis |
| negative regulation of catalytic activity |
| regulation of secretion |
| regulation of neurogenesis |
| cation transport |
| peptidyl-amino acid modification |
| cellular homeostasis |
| regulation of cellular localization |
| response to organic cyclic compound |
| regulation of nervous system development |
| leukocyte activation |
| regulation of cell development |
| ion transmembrane transport |
| positive regulation of cell differentiation |
| secretion by cell |
| response to drug |
| regulation of protein localization |
| negative regulation of cellular protein metabolic process |
| export from cell |
| cell activation |
| regulation of response to external stimulus |
| negative regulation of protein metabolic process |
| chemical homeostasis |
| cell-cell signaling |
| secretion |
| negative regulation of molecular function |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| negative regulation of signal transduction |
| transmembrane transport |
| regulation of hydrolase activity |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| ion transport |
| nervous system process |
| regulation of response to stress |
| protein transport |
| generation of neurons |
| peptide transport |
| response to oxygen-containing compound |
| amide transport |
| establishment of protein localization |
| negative regulation of response to stimulus |
| neurogenesis |
| homeostatic process |
| intracellular signal transduction |
| positive regulation of multicellular organismal process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| regulation of protein modification process |
| nitrogen compound transport |
| regulation of transport |
| system process |
| membrane |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| SNS-032 15μM R08 exp443 | -2.19 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15942
- Expression level (log2 read counts): -0.12
Expression Distribution
FKBP1B Expression in NALM6 Cells: -0.12
