GAB1
Gene Information
- Official Symbol: GAB1
- Official Name: GRB2 associated binding protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 2549
- UniProt: Q13480
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR).
Pfam Domains GO Terms
Pfam Domains
| PH |
GO Terms
| endothelial cell chemotaxis to vascular endothelial growth factor |
| cell chemotaxis to vascular endothelial growth factor |
| positive regulation of cell migration by vascular endothelial growth factor signaling pathway |
| response to hepatocyte growth factor |
| vascular endothelial growth factor signaling pathway |
| ERBB2 signaling pathway |
| cellular response to vascular endothelial growth factor stimulus |
| epidermal growth factor receptor signaling pathway |
| SH3/SH2 adaptor activity |
| actin cytoskeleton reorganization |
| ERBB signaling pathway |
| positive regulation of phosphatidylinositol 3-kinase signaling |
| insulin receptor signaling pathway |
| regulation of phosphatidylinositol 3-kinase signaling |
| cellular response to insulin stimulus |
| positive regulation of angiogenesis |
| positive regulation of protein kinase B signaling |
| cell-cell junction |
| positive regulation of vasculature development |
| cell chemotaxis |
| regulation of protein kinase B signaling |
| response to insulin |
| axon guidance |
| neuron projection guidance |
| cellular response to peptide hormone stimulus |
| regulation of angiogenesis |
| angiogenesis |
| regulation of vasculature development |
| cellular response to peptide |
| axonogenesis |
| response to peptide hormone |
| blood vessel morphogenesis |
| axon development |
| cell morphogenesis involved in neuron differentiation |
| response to peptide |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| blood vessel development |
| cell projection morphogenesis |
| actin cytoskeleton organization |
| cellular response to growth factor stimulus |
| positive regulation of cell migration |
| vasculature development |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| cell part morphogenesis |
| cardiovascular system development |
| positive regulation of cell motility |
| response to growth factor |
| positive regulation of cellular component movement |
| chemotaxis |
| taxis |
| positive regulation of locomotion |
| cell morphogenesis involved in differentiation |
| actin filament-based process |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| tube morphogenesis |
| cellular response to nitrogen compound |
| neuron projection development |
| enzyme linked receptor protein signaling pathway |
| cell morphogenesis |
| neuron development |
| cellular component morphogenesis |
| tube development |
| regulation of cell migration |
| circulatory system development |
| anatomical structure formation involved in morphogenesis |
| response to hormone |
| regulation of cell motility |
| cell migration |
| regulation of locomotion |
| regulation of cellular component movement |
| response to organonitrogen compound |
| neuron differentiation |
| positive regulation of intracellular signal transduction |
| cellular response to oxygen-containing compound |
| regulation of anatomical structure morphogenesis |
| localization of cell |
| cell motility |
| response to nitrogen compound |
| cytoskeleton organization |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| cellular response to endogenous stimulus |
| locomotion |
| positive regulation of developmental process |
| response to endogenous stimulus |
| generation of neurons |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| neurogenesis |
| cell development |
| positive regulation of signal transduction |
| positive regulation of multicellular organismal process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Lapatinib 5μM R01 exp47 | 1.73 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 6/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 1/13 |
| fibroblast | 0/1 |
| gastric | 1/16 |
| kidney | 1/21 |
| liver | 0/20 |
| lung | 1/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 1/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8423
- Expression level (log2 read counts): 6.92
Expression Distribution
GAB1 Expression in NALM6 Cells: 6.92
