GBX1
Gene Information
- Official Symbol: GBX1
- Official Name: gastrulation brain homeobox 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 2636
- UniProt: Q14549
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Homeobox |
GO Terms
| sensory neuron axon guidance |
| proprioception |
| neuromuscular process controlling posture |
| adult walking behavior |
| walking behavior |
| spinal cord motor neuron differentiation |
| ventral spinal cord development |
| cell differentiation in spinal cord |
| neuron fate commitment |
| adult locomotory behavior |
| cerebellum development |
| spinal cord development |
| neuromuscular process |
| metencephalon development |
| adult behavior |
| hindbrain development |
| central nervous system neuron differentiation |
| locomotory behavior |
| cell fate commitment |
| axon guidance |
| neuron projection guidance |
| RNA polymerase II regulatory region sequence-specific DNA binding |
| axonogenesis |
| axon development |
| cell morphogenesis involved in neuron differentiation |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| cell part morphogenesis |
| chemotaxis |
| taxis |
| cell morphogenesis involved in differentiation |
| behavior |
| neuron projection development |
| cell morphogenesis |
| brain development |
| head development |
| neuron development |
| cellular component morphogenesis |
| regulation of nervous system development |
| sensory perception |
| central nervous system development |
| neuron differentiation |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| positive regulation of transcription by RNA polymerase II |
| locomotion |
| nervous system process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| movement of cell or subcellular component |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| positive regulation of RNA metabolic process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| A-366 10μM R03 exp115 | -2.37 |
| 4-Nitroquinoline-1-oxide 0.5μM R08 exp446 | -1.76 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13113
- Expression level (log2 read counts): -4.6
Expression Distribution
GBX1 Expression in NALM6 Cells: -4.6
