GIPC1

Gene Information

Official Symbol: GIPC1
Official Name: GIPC PDZ domain containing family member 1
Aliases and Previous Symbols: N/A
Entrez ID: 10755
UniProt: O14908
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May be involved in G protein-linked signaling.

Pfam Domains GO Terms

Pfam Domains

PDZ

GO Terms

positive regulation of melanin biosynthetic process

positive regulation of secondary metabolite biosynthetic process

regulation of melanin biosynthetic process

regulation of secondary metabolite biosynthetic process

regulation of secondary metabolic process

myosin binding

positive regulation of cellular response to transforming growth factor beta stimulus

vesicle membrane

cellular response to interleukin-7

glutamate secretion

positive regulation of transforming growth factor beta receptor signaling pathway

response to interleukin-7

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

dendritic shaft

positive regulation of cytokinesis

acidic amino acid transport

negative regulation of ubiquitin-dependent protein catabolic process

brush border

negative regulation of proteasomal protein catabolic process

endocytic vesicle

endothelial cell migration

negative regulation of proteolysis involved in cellular protein catabolic process

regulation of synaptic vesicle exocytosis

dicarboxylic acid transport

acid secretion

Schaffer collateral - CA1 synapse

epithelial cell migration

positive regulation of cell division

epithelium migration

negative regulation of cellular protein catabolic process

PDZ domain binding

regulation of cytokinesis

tissue migration

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

regulation of neurotransmitter secretion

regulation of synaptic vesicle cycle

regulation of transforming growth factor beta receptor signaling pathway

regulation of cellular response to transforming growth factor beta stimulus

amino acid transport

synaptic vesicle

regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of protein catabolic process

cell cortex

regulation of neurotransmitter transport

dendritic spine

regulation of ubiquitin-dependent protein catabolic process

regulation of regulated secretory pathway

regulation of cell division

ameboidal-type cell migration

regulation of proteasomal protein catabolic process

regulation of synaptic plasticity

regulation of proteolysis involved in cellular protein catabolic process

regulation of exocytosis

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

regulation of cellular protein catabolic process

cytoplasmic vesicle

negative regulation of cellular catabolic process

actin binding

regulation of cellular response to growth factor stimulus

positive regulation of cell cycle process

regulation of protein stability

organic acid transport

carboxylic acid transport

cadherin binding

negative regulation of catabolic process

signaling receptor binding

glutamatergic synapse

negative regulation of proteolysis

regulation of neurotransmitter levels

protein targeting

positive regulation of cell cycle

regulation of protein catabolic process

chemical synaptic transmission

anterograde trans-synaptic signaling

trans-synaptic signaling

modulation of chemical synaptic transmission

regulation of trans-synaptic signaling

organic anion transport

synaptic signaling

regulation of vesicle-mediated transport

anion transport

regulation of proteolysis

regulation of secretion by cell

regulation of cell cycle process

regulation of secretion

regulation of cellular catabolic process

protein homodimerization activity

regulation of cellular localization

cell migration

intracellular protein transport

regulation of catabolic process

secretion by cell

cellular response to cytokine stimulus

negative regulation of cellular protein metabolic process

export from cell

cell motility

localization of cell

response to cytokine

negative regulation of protein metabolic process

cell-cell signaling

secretion

regulation of cell cycle

locomotion

G protein-coupled receptor signaling pathway

ion transport

protein transport

intracellular transport

peptide transport

movement of cell or subcellular component

amide transport

cellular protein localization

cellular macromolecule localization

establishment of protein localization

positive regulation of signal transduction

positive regulation of cell communication

positive regulation of signaling

establishment of localization in cell

nitrogen compound transport

regulation of transport

positive regulation of cellular biosynthetic process

membrane

positive regulation of biosynthetic process

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Compound Hit

Screen	Score
Temozolomide 200μM R04 exp189	1.73
Dihydrosphingosine 8μM R08 exp476	1.8

Most Correlated Genes in Chemogenomics

No correlation found to any other genes in chemogenomics.

Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2824
Expression level (log2 read counts): 4.21

Expression Distribution