GJB3
Gene Information
- Official Symbol: GJB3
- Official Name: gap junction protein beta 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 2707
- UniProt: O75712
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene can cause non-syndromic deafness or erythrokeratodermia variabilis, a skin disorder. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008].
- UniProt Summary: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 4817
- Expression level (log2 read counts): -7.68
GJB3 Expression in NALM6 Cells: -7.68
