GMFB
Gene Information
- Official Symbol: GMFB
- Official Name: glia maturation factor beta
- Aliases and Previous Symbols: N/A
- Entrez ID: 2764
- UniProt: P60983
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells.
Pfam Domains GO Terms
Pfam Domains
| Cofilin ADF |
GO Terms
| actin filament debranching |
| negative regulation of Arp2/3 complex-mediated actin nucleation |
| actin filament severing |
| negative regulation of actin nucleation |
| Arp2/3 complex binding |
| regulation of Arp2/3 complex-mediated actin nucleation |
| actin cortical patch |
| regulation of actin nucleation |
| protein kinase inhibitor activity |
| enzyme activator activity |
| negative regulation of supramolecular fiber organization |
| negative regulation of cytoskeleton organization |
| learning |
| growth factor activity |
| regulation of actin filament polymerization |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| locomotory behavior |
| regulation of protein polymerization |
| negative regulation of protein kinase activity |
| negative regulation of kinase activity |
| learning or memory |
| regulation of actin filament organization |
| actin binding |
| negative regulation of transferase activity |
| cognition |
| regulation of actin cytoskeleton organization |
| regulation of supramolecular fiber organization |
| negative regulation of organelle organization |
| regulation of cellular component size |
| regulation of actin filament-based process |
| negative regulation of protein phosphorylation |
| negative regulation of phosphorylation |
| regulation of protein complex assembly |
| regulation of anatomical structure size |
| regulation of cytoskeleton organization |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| actin filament-based process |
| behavior |
| negative regulation of protein modification process |
| negative regulation of cellular component organization |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| regulation of kinase activity |
| regulation of cellular component biogenesis |
| protein phosphorylation |
| regulation of transferase activity |
| negative regulation of cellular protein metabolic process |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| phosphorylation |
| regulation of organelle organization |
| nervous system process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of phosphorylation |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| BI-6727 0.0125μM R03 exp97 | 1.74 |
| Radicicol 0.16μM R05 exp242 | 1.75 |
| Vinblastine 0.002μM R01 exp60 | 1.78 |
| Actinomycin-D 0.001μM R00 exp3 | 2.02 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14702
- Expression level (log2 read counts): 6.21
Expression Distribution
GMFB Expression in NALM6 Cells: 6.21
