GNAI1
Gene Information
- Official Symbol: GNAI1
- Official Name: G protein subunit alpha i1
- Aliases and Previous Symbols: N/A
- Entrez ID: 2770
- UniProt: P63096
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| G-alpha |
| Arf |
GO Terms
| G protein-coupled serotonin receptor binding |
| positive regulation of protein localization to cell cortex |
| regulation of protein localization to cell cortex |
| cellular response to forskolin |
| response to forskolin |
| response to platelet aggregation inhibitor |
| cell cortex region |
| GTPase activating protein binding |
| G-protein beta/gamma-subunit complex binding |
| heterotrimeric G-protein complex |
| regulation of mitotic spindle organization |
| regulation of spindle organization |
| regulation of cAMP-mediated signaling |
| negative regulation of synaptic transmission |
| positive regulation of protein localization to cell periphery |
| G protein-coupled receptor binding |
| GDP binding |
| cellular response to alcohol |
| adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| cellular response to ketone |
| regulation of protein localization to cell periphery |
| cellular response to antibiotic |
| midbody |
| regulation of microtubule cytoskeleton organization |
| response to ketone |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| magnesium ion binding |
| regulation of microtubule-based process |
| membrane raft |
| protein folding |
| response to alcohol |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| lysosomal membrane |
| response to antibiotic |
| positive regulation of cellular protein localization |
| GTPase activity |
| GTP binding |
| response to peptide hormone |
| cellular response to drug |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| response to peptide |
| centrosome |
| cell division |
| cellular response to lipid |
| regulation of cellular protein localization |
| regulation of cytoskeleton organization |
| cellular response to organic cyclic compound |
| regulation of mitotic cell cycle |
| regulation of cell cycle process |
| response to lipid |
| nucleolus |
| response to hormone |
| regulation of cellular localization |
| response to organic cyclic compound |
| response to organonitrogen compound |
| response to drug |
| regulation of protein localization |
| cellular response to oxygen-containing compound |
| response to nitrogen compound |
| regulation of cell cycle |
| regulation of organelle organization |
| G protein-coupled receptor signaling pathway |
| cell cycle |
| negative regulation of cell communication |
| negative regulation of signaling |
| response to endogenous stimulus |
| response to oxygen-containing compound |
| regulation of intracellular signal transduction |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| BI-6727 0.04μM R03 exp98 | 1.73 |
| Dimethyl-Sulfoxide 1pc R03 exp120 | 2.02 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17216
- Expression level (log2 read counts): 3.28
Expression Distribution
GNAI1 Expression in NALM6 Cells: 3.28
