UniProt Summary: Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.
Pfam DomainsGO Terms
Pfam Domains
GSHPx
GO Terms
glutathione peroxidase activity
peroxidase activity
electron transfer activity
cellular oxidant detoxification
cellular detoxification
detoxification
electron transport chain
cellular response to toxic substance
cellular response to oxidative stress
response to oxidative stress
generation of precursor metabolites and energy
response to toxic substance
oxidation-reduction process
cellular response to stress
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739