GRPEL2
Gene Information
- Official Symbol: GRPEL2
- Official Name: GrpE like 2, mitochondrial
- Aliases and Previous Symbols: N/A
- Entrez ID: 134266
- UniProt: Q8TAA5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity). {ECO:0000250}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 16373
- Expression level (log2 read counts): 0.52
GRPEL2 Expression in NALM6 Cells: 0.52
