GSTM2
Gene Information
- Official Symbol: GSTM2
- Official Name: glutathione S-transferase mu 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 2946
- UniProt: P28161
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. {ECO:0000269|PubMed:16549767}.
Pfam Domains GO Terms
Pfam Domains
| GST N |
| GST C |
GO Terms
| cellular detoxification of nitrogen compound |
| regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion |
| nitrobenzene metabolic process |
| regulation of skeletal muscle contraction by calcium ion signaling |
| detoxification of nitrogen compound |
| positive regulation of ryanodine-sensitive calcium-release channel activity |
| cellular response to caffeine |
| glutathione binding |
| negative regulation of ryanodine-sensitive calcium-release channel activity |
| regulation of skeletal muscle contraction |
| cellular response to purine-containing compound |
| xenobiotic catabolic process |
| relaxation of cardiac muscle |
| negative regulation of release of sequestered calcium ion into cytosol |
| positive regulation of sequestering of calcium ion |
| linoleic acid metabolic process |
| response to diuretic |
| response to caffeine |
| negative regulation of calcium ion transport into cytosol |
| regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| glutathione peroxidase activity |
| relaxation of muscle |
| glutathione derivative metabolic process |
| glutathione derivative biosynthetic process |
| regulation of cardiac muscle contraction by calcium ion signaling |
| benzene-containing compound metabolic process |
| regulation of ryanodine-sensitive calcium-release channel activity |
| regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| glutathione transferase activity |
| negative regulation of calcium-mediated signaling |
| cellular response to alkaloid |
| negative regulation of calcium ion transmembrane transporter activity |
| positive regulation of calcium ion transmembrane transporter activity |
| negative regulation of calcium ion transmembrane transport |
| positive regulation of release of sequestered calcium ion into cytosol |
| positive regulation of calcium-mediated signaling |
| negative regulation of cation channel activity |
| sarcoplasmic reticulum |
| positive regulation of calcium ion transport into cytosol |
| glutathione metabolic process |
| intercellular bridge |
| negative regulation of calcium ion transport |
| positive regulation of cation channel activity |
| positive regulation of calcium ion transmembrane transport |
| negative regulation of ion transmembrane transporter activity |
| regulation of cardiac muscle contraction |
| regulation of release of sequestered calcium ion into cytosol |
| negative regulation of transporter activity |
| negative regulation of cation transmembrane transport |
| regulation of calcium ion transmembrane transporter activity |
| cellular oxidant detoxification |
| regulation of striated muscle contraction |
| negative regulation of ion transmembrane transport |
| regulation of calcium-mediated signaling |
| regulation of calcium ion transport into cytosol |
| cellular detoxification |
| positive regulation of ion transmembrane transporter activity |
| unsaturated fatty acid metabolic process |
| positive regulation of transporter activity |
| response to alkaloid |
| long-chain fatty acid metabolic process |
| negative regulation of transmembrane transport |
| positive regulation of calcium ion transport |
| regulation of sequestering of calcium ion |
| detoxification |
| xenobiotic metabolic process |
| positive regulation of cation transmembrane transport |
| calcium-mediated signaling |
| negative regulation of ion transport |
| regulation of calcium ion transmembrane transport |
| response to purine-containing compound |
| positive regulation of ion transmembrane transport |
| regulation of muscle contraction |
| regulation of cation channel activity |
| sulfur compound biosynthetic process |
| cellular response to xenobiotic stimulus |
| cellular modified amino acid metabolic process |
| positive regulation of transmembrane transport |
| cellular response to toxic substance |
| regulation of muscle system process |
| regulation of heart contraction |
| regulation of calcium ion transport |
| regulation of ion transmembrane transporter activity |
| regulation of transmembrane transporter activity |
| positive regulation of ion transport |
| regulation of transporter activity |
| positive regulation of cytosolic calcium ion concentration |
| regulation of blood circulation |
| muscle system process |
| response to xenobiotic stimulus |
| fatty acid metabolic process |
| regulation of cytosolic calcium ion concentration |
| regulation of cation transmembrane transport |
| signaling receptor binding |
| second-messenger-mediated signaling |
| enzyme binding |
| sulfur compound metabolic process |
| regulation of metal ion transport |
| cellular response to drug |
| cellular calcium ion homeostasis |
| cofactor metabolic process |
| calcium ion homeostasis |
| cellular divalent inorganic cation homeostasis |
| regulation of ion transmembrane transport |
| negative regulation of transport |
| divalent inorganic cation homeostasis |
| response to toxic substance |
| negative regulation of intracellular signal transduction |
| peptide metabolic process |
| monocarboxylic acid metabolic process |
| cellular response to organic cyclic compound |
| cellular metal ion homeostasis |
| regulation of transmembrane transport |
| regulation of system process |
| cellular response to organonitrogen compound |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| cellular response to nitrogen compound |
| regulation of ion transport |
| cation homeostasis |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| ion homeostasis |
| cellular amide metabolic process |
| protein homodimerization activity |
| cellular homeostasis |
| carboxylic acid metabolic process |
| regulation of cellular localization |
| response to organic cyclic compound |
| cellular lipid metabolic process |
| positive regulation of transport |
| response to organonitrogen compound |
| oxoacid metabolic process |
| response to drug |
| positive regulation of intracellular signal transduction |
| organic acid metabolic process |
| response to nitrogen compound |
| chemical homeostasis |
| negative regulation of molecular function |
| lipid metabolic process |
| cellular response to endogenous stimulus |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| organonitrogen compound biosynthetic process |
| response to endogenous stimulus |
| negative regulation of response to stimulus |
| homeostatic process |
| positive regulation of signal transduction |
| intracellular signal transduction |
| cellular response to stress |
| small molecule metabolic process |
| positive regulation of molecular function |
| cellular catabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8978
- Expression level (log2 read counts): 4.62
Expression Distribution
GSTM2 Expression in NALM6 Cells: 4.62
