UniProt Summary: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
Pfam DomainsGO Terms
Pfam Domains
TFIIE alpha
TFIIE-A C-term
TF Zn Ribbon
GO Terms
transcriptional open complex formation at RNA polymerase II promoter
protein-DNA complex remodeling
DNA-templated transcriptional open complex formation
transcription factor TFIIE complex
TFIIH-class transcription factor complex binding
transcriptional preinitiation complex
RNA polymerase II general transcription initiation factor activity
protein-containing complex remodeling
RNA polymerase II complex binding
transcription factor TFIID complex
snRNA transcription by RNA polymerase II
snRNA transcription
ncRNA transcription
transcription initiation from RNA polymerase II promoter
DNA-templated transcription, initiation
protein-DNA complex subunit organization
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
viral process
symbiotic process
interspecies interaction between organisms
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
protein-containing complex subunit organization
gene expression
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 568/726