Pfam Domains GO Terms
| Guanylate cyc |
| HNOBA |
| HNOB |
| retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission |
| response to defense-related host nitric oxide production |
| response to defense-related nitric oxide production by other organism involved in symbiotic interaction |
| trans-synaptic signaling by soluble gas, modulating synaptic transmission |
| retrograde trans-synaptic signaling by soluble gas |
| guanylate cyclase complex, soluble |
| trans-synaptic signaling by nitric oxide, modulating synaptic transmission |
| retrograde trans-synaptic signaling by nitric oxide |
| synaptic signaling by nitric oxide |
| trans-synaptic signaling by nitric oxide |
| trans-synaptic signaling by soluble gas |
| positive regulation of nitric oxide mediated signal transduction |
| response to host immune response |
| response to immune response of other organism involved in symbiotic interaction |
| response to defenses of other organism involved in symbiotic interaction |
| response to host |
| retrograde trans-synaptic signaling |
| response to host defenses |
| relaxation of vascular smooth muscle |
| relaxation of smooth muscle |
| guanylate cyclase activity |
| regulation of nitric oxide mediated signal transduction |
| cGMP biosynthetic process |
| trans-synaptic signaling, modulating synaptic transmission |
| negative regulation of smooth muscle contraction |
| cGMP metabolic process |
| nitric oxide mediated signal transduction |
| relaxation of muscle |
| cyclic nucleotide biosynthetic process |
| negative regulation of muscle contraction |
| cyclic purine nucleotide metabolic process |
| vasodilation |
| cyclic nucleotide metabolic process |
| positive regulation of blood vessel diameter |
| regulation of smooth muscle contraction |
| GABA-ergic synapse |
| regulation of blood vessel diameter |
| regulation of tube diameter |
| regulation of tube size |
| heme binding |
| purine ribonucleotide biosynthetic process |
| interaction with host |
| purine nucleotide biosynthetic process |
| regulation of muscle contraction |
| ribonucleotide biosynthetic process |
| vascular process in circulatory system |
| ribose phosphate biosynthetic process |
| purine-containing compound biosynthetic process |
| regulation of blood pressure |
| signaling receptor activity |
| regulation of muscle system process |
| nucleotide biosynthetic process |
| nucleoside phosphate biosynthetic process |
| muscle system process |
| purine ribonucleotide metabolic process |
| ribonucleotide metabolic process |
| purine nucleotide metabolic process |
| ribose phosphate metabolic process |
| second-messenger-mediated signaling |
| glutamatergic synapse |
| purine-containing compound metabolic process |
| GTP binding |
| blood circulation |
| circulatory system process |
| trans-synaptic signaling |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| synaptic signaling |
| regulation of anatomical structure size |
| organophosphate biosynthetic process |
| nucleobase-containing small molecule metabolic process |
| regulation of system process |
| carbohydrate derivative biosynthetic process |
| symbiotic process |
| interspecies interaction between organisms |
| organophosphate metabolic process |
| positive regulation of intracellular signal transduction |
| carbohydrate derivative metabolic process |
| nucleobase-containing compound biosynthetic process |
| cell-cell signaling |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of multicellular organismal process |
| response to other organism |
| organic cyclic compound biosynthetic process |
| response to external biotic stimulus |
| response to biotic stimulus |
| organonitrogen compound biosynthetic process |
| cellular nitrogen compound biosynthetic process |
| positive regulation of signal transduction |
| intracellular signal transduction |
| small molecule metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| system process |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Screen | Score |
|---|---|
| UMK57 1μM R01 exp59 | -1.85 |
| Rotenone 0.07μM R08 exp431 | -1.77 |
| Hippuristanol 0.12μM R08 exp489 no dilution day6 | 1.71 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Expression Distribution