HEG1
Gene Information
- Official Symbol: HEG1
- Official Name: heart development protein with EGF like domains 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 57493
- UniProt: Q9ULI3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity May act through the stabilization of endothelial cell junctions. {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| EGF CA |
GO Terms
| lymph circulation |
| negative regulation of Rho-dependent protein serine/threonine kinase activity |
| regulation of Rho-dependent protein serine/threonine kinase activity |
| positive regulation of fibroblast growth factor production |
| negative regulation of membrane permeability |
| regulation of fibroblast growth factor production |
| venous blood vessel morphogenesis |
| protein localization to cell junction |
| endothelial cell morphogenesis |
| venous blood vessel development |
| ventricular trabecula myocardium morphogenesis |
| pericardium development |
| lymph vessel development |
| negative regulation of Rho protein signal transduction |
| cardiac muscle tissue growth |
| heart growth |
| cardiac atrium morphogenesis |
| heart trabecula morphogenesis |
| epithelial cell morphogenesis |
| cardiac atrium development |
| trabecula morphogenesis |
| ventricular cardiac muscle tissue morphogenesis |
| endothelial cell development |
| negative regulation of Ras protein signal transduction |
| ventricular cardiac muscle tissue development |
| negative regulation of small GTPase mediated signal transduction |
| vasculogenesis |
| cardiac muscle tissue morphogenesis |
| ventricular septum development |
| cardiac ventricle morphogenesis |
| muscle tissue morphogenesis |
| regulation of membrane permeability |
| endothelial cell differentiation |
| multicellular organism growth |
| muscle organ morphogenesis |
| post-embryonic development |
| endothelium development |
| organ growth |
| cell-cell junction assembly |
| cardiac septum development |
| cardiac chamber morphogenesis |
| cardiac ventricle development |
| negative regulation of protein serine/threonine kinase activity |
| cell-cell junction organization |
| regulation of Rho protein signal transduction |
| cytokine production |
| cardiac muscle tissue development |
| cell junction assembly |
| lung development |
| cardiac chamber development |
| cell-cell junction |
| respiratory tube development |
| epithelial cell development |
| respiratory system development |
| cell junction organization |
| negative regulation of protein kinase activity |
| regulation of Ras protein signal transduction |
| negative regulation of kinase activity |
| heart morphogenesis |
| negative regulation of transferase activity |
| striated muscle tissue development |
| muscle organ development |
| muscle tissue development |
| regulation of small GTPase mediated signal transduction |
| in utero embryonic development |
| developmental growth |
| growth |
| external side of plasma membrane |
| circulatory system process |
| negative regulation of protein phosphorylation |
| blood vessel morphogenesis |
| negative regulation of phosphorylation |
| positive regulation of cytokine production |
| muscle structure development |
| blood vessel development |
| regulation of body fluid levels |
| negative regulation of intracellular signal transduction |
| vasculature development |
| regulation of protein serine/threonine kinase activity |
| cardiovascular system development |
| heart development |
| cell morphogenesis involved in differentiation |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| tissue morphogenesis |
| negative regulation of protein modification process |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| epithelial cell differentiation |
| regulation of cytokine production |
| calcium ion binding |
| cell morphogenesis |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| cellular component morphogenesis |
| tube development |
| circulatory system development |
| regulation of kinase activity |
| animal organ morphogenesis |
| embryo development |
| regulation of transferase activity |
| negative regulation of cellular protein metabolic process |
| negative regulation of protein metabolic process |
| epithelium development |
| negative regulation of molecular function |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| regulation of protein phosphorylation |
| regulation of phosphorylation |
| negative regulation of response to stimulus |
| cell development |
| positive regulation of multicellular organismal process |
| tissue development |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| extracellular region |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7546
- Expression level (log2 read counts): 4.83
Expression Distribution
HEG1 Expression in NALM6 Cells: 4.83
