HERC1
Gene Information
- Official Symbol: HERC1
- Official Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 8925
- UniProt: Q15751
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gen encodes a member of the HERC protein family. This protein stimulates guanine nucleotide exchange on ARF1 and Rab proteins. This protein may be involved in membrane transport processes. [provided by RefSeq, Mar 2012].
- UniProt Summary: Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin- protein ligase which accepts ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. {ECO:0000269|PubMed:15642342, ECO:0000269|PubMed:8861955, ECO:0000269|PubMed:9233772}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 3924
- Expression level (log2 read counts): 7.43
HERC1 Expression in NALM6 Cells: 7.43
