HES1
Gene Information
- Official Symbol: HES1
- Official Name: hes family bHLH transcription factor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 3280
- UniProt: Q14469
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage. {ECO:0000250, ECO:0000269|PubMed:18550849}.
Pfam Domains GO Terms
Pfam Domains
| Hairy orange |
| HLH |
GO Terms
| regulation of stomach neuroendocrine cell differentiation |
| regulation of pancreatic A cell differentiation |
| regulation of cell fate determination |
| negative regulation of pancreatic A cell differentiation |
| negative regulation of stomach neuroendocrine cell differentiation |
| N-box binding |
| negative regulation of cell fate determination |
| positive regulation of mitotic cell cycle, embryonic |
| kidney interstitial fibroblast differentiation |
| cell-cell signaling involved in cell fate commitment |
| renal interstitial fibroblast development |
| lateral inhibition |
| trochlear nerve development |
| negative regulation of lymphoid progenitor cell differentiation |
| negative regulation of forebrain neuron differentiation |
| negative regulation of pro-B cell differentiation |
| regulation of timing of neuron differentiation |
| common bile duct development |
| midbrain-hindbrain boundary morphogenesis |
| ascending aorta morphogenesis |
| regulation of mitotic cell cycle, embryonic |
| negative regulation of inner ear auditory receptor cell differentiation |
| negative regulation of inner ear receptor cell differentiation |
| negative regulation of mechanoreceptor differentiation |
| oculomotor nerve development |
| regulation of forebrain neuron differentiation |
| inhibition of neuroepithelial cell differentiation |
| comma-shaped body morphogenesis |
| ascending aorta development |
| cardiac neural crest cell development involved in outflow tract morphogenesis |
| forebrain radial glial cell differentiation |
| regulation of pro-B cell differentiation |
| S-shaped body morphogenesis |
| negative regulation of hematopoietic progenitor cell differentiation |
| metanephric nephron tubule morphogenesis |
| cardiac neural crest cell differentiation involved in heart development |
| regulation of inner ear auditory receptor cell differentiation |
| regulation of mechanoreceptor differentiation |
| pharyngeal arch artery morphogenesis |
| regulation of inner ear receptor cell differentiation |
| regulation of lymphoid progenitor cell differentiation |
| cardiac neural crest cell development involved in heart development |
| regulation of secondary heart field cardioblast proliferation |
| vascular smooth muscle cell development |
| midbrain-hindbrain boundary development |
| regulation of cardioblast proliferation |
| metanephric tubule morphogenesis |
| rostrocaudal neural tube patterning |
| radial glial cell differentiation |
| positive regulation of astrocyte differentiation |
| regulation of timing of cell differentiation |
| adenohypophysis development |
| negative regulation of oligodendrocyte differentiation |
| negative regulation of cell fate commitment |
| vascular smooth muscle cell differentiation |
| negative regulation of glial cell proliferation |
| negative regulation of epidermal cell differentiation |
| regulation of development, heterochronic |
| metanephric nephron tubule development |
| metanephric nephron epithelium development |
| regulation of cell proliferation involved in heart morphogenesis |
| preganglionic parasympathetic fiber development |
| metanephric tubule development |
| glomerulus vasculature development |
| negative regulation of epidermis development |
| labyrinthine layer blood vessel development |
| parasympathetic nervous system development |
| renal system vasculature development |
| kidney vasculature development |
| metanephric nephron morphogenesis |
| metanephric epithelium development |
| negative regulation of stem cell differentiation |
| neuronal stem cell population maintenance |
| negative regulation of glial cell differentiation |
| pharyngeal system development |
| regulation of astrocyte differentiation |
| metanephros morphogenesis |
| regulation of cell fate commitment |
| inner ear receptor cell stereocilium organization |
| aorta morphogenesis |
| placenta blood vessel development |
| regulation of glial cell proliferation |
| establishment of epithelial cell polarity |
| metanephric nephron development |
| positive regulation of BMP signaling pathway |
| smooth muscle cell differentiation |
| neural tube patterning |
| regulation of animal organ formation |
| positive regulation of embryonic development |
| regulation of oligodendrocyte differentiation |
| regulation of heart morphogenesis |
| negative regulation of gliogenesis |
| cell differentiation involved in kidney development |
| hindbrain morphogenesis |
| ventricular septum morphogenesis |
| negative regulation of epithelial cell differentiation |
| inner ear receptor cell development |
| pituitary gland development |
| positive regulation of glial cell differentiation |
| autonomic nervous system development |
| thymus development |
| labyrinthine layer development |
| E-box binding |
| glomerulus development |
| cochlea development |
| aorta development |
| cranial nerve development |
| positive regulation of Notch signaling pathway |
| inner ear receptor cell differentiation |
| ureteric bud morphogenesis |
| mesonephric tubule morphogenesis |
| positive regulation of DNA binding |
| mechanoreceptor differentiation |
| regulation of epidermal cell differentiation |
| artery morphogenesis |
| nephron tubule morphogenesis |
| somatic stem cell population maintenance |
| nephron epithelium morphogenesis |
| forebrain generation of neurons |
| embryonic heart tube morphogenesis |
| nephron morphogenesis |
| renal tubule morphogenesis |
| positive regulation of tyrosine phosphorylation of STAT protein |
| regulation of glial cell differentiation |
| positive regulation of gliogenesis |
| pancreas development |
| smoothened signaling pathway |
| ventricular septum development |
| outflow tract morphogenesis |
| cardiac septum morphogenesis |
| diencephalon development |
| embryonic heart tube development |
| nephron tubule development |
| nerve development |
| regulation of tyrosine phosphorylation of STAT protein |
| neural crest cell development |
| renal tubule development |
| metanephros development |
| stem cell development |
| mesenchymal cell development |
| kidney morphogenesis |
| positive regulation of receptor signaling pathway via JAK-STAT |
| regulation of epidermis development |
| artery development |
| ureteric bud development |
| midbrain development |
| regulation of hematopoietic progenitor cell differentiation |
| mesonephric epithelium development |
| embryonic placenta development |
| mesonephric tubule development |
| regulation of BMP signaling pathway |
| positive regulation of receptor signaling pathway via STAT |
| neural crest cell differentiation |
| mesonephros development |
| positive regulation of T cell proliferation |
| nephron epithelium development |
| chaperone binding |
| regulation of Notch signaling pathway |
| positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| cardiac septum development |
| histone deacetylase binding |
| regulation of gliogenesis |
| cardiocyte differentiation |
| establishment of cell polarity |
| regulation of stem cell differentiation |
| endocrine system development |
| regulation of fat cell differentiation |
| nephron development |
| liver development |
| Notch signaling pathway |
| regulation of DNA binding |
| cardiac chamber morphogenesis |
| cardiac ventricle development |
| regulation of embryonic development |
| hepaticobiliary system development |
| kidney epithelium development |
| regulation of receptor signaling pathway via JAK-STAT |
| positive regulation of lymphocyte proliferation |
| positive regulation of mononuclear cell proliferation |
| regulation of receptor signaling pathway via STAT |
| stem cell population maintenance |
| negative regulation of hemopoiesis |
| maintenance of cell number |
| positive regulation of leukocyte proliferation |
| regulation of epithelial cell differentiation |
| muscle cell development |
| hindbrain development |
| positive regulation of mitotic cell cycle |
| placenta development |
| regulation of T cell proliferation |
| mesenchymal cell differentiation |
| stem cell differentiation |
| cell maturation |
| neural tube development |
| lung development |
| glial cell differentiation |
| cardiac chamber development |
| respiratory tube development |
| positive regulation of binding |
| positive regulation of peptidyl-tyrosine phosphorylation |
| inner ear development |
| respiratory system development |
| establishment or maintenance of cell polarity |
| positive regulation of T cell activation |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| gliogenesis |
| positive regulation of leukocyte cell-cell adhesion |
| anterior/posterior pattern specification |
| mesenchyme development |
| ear development |
| regulation of leukocyte proliferation |
| negative regulation of neuron differentiation |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| developmental maturation |
| muscle cell differentiation |
| DNA-binding transcription repressor activity, RNA polymerase II-specific |
| cell fate commitment |
| heart morphogenesis |
| regulation of peptidyl-tyrosine phosphorylation |
| positive regulation of cell-cell adhesion |
| telencephalon development |
| regulation of animal organ morphogenesis |
| kidney development |
| regulation of cellular response to growth factor stimulus |
| renal system development |
| embryonic organ morphogenesis |
| negative regulation of neurogenesis |
| regulation of leukocyte cell-cell adhesion |
| epithelial tube morphogenesis |
| negative regulation of nervous system development |
| RNA polymerase II regulatory region sequence-specific DNA binding |
| regulation of T cell activation |
| urogenital system development |
| regionalization |
| transcription factor binding |
| regulation of epithelial cell proliferation |
| negative regulation of cell development |
| positive regulation of lymphocyte activation |
| in utero embryonic development |
| regulation of binding |
| positive regulation of cell cycle |
| forebrain development |
| regulation of cell-cell adhesion |
| positive regulation of cell adhesion |
| positive regulation of leukocyte activation |
| blood vessel morphogenesis |
| gland development |
| positive regulation of cell activation |
| sequence-specific DNA binding |
| reproductive structure development |
| reproductive system development |
| cell morphogenesis involved in neuron differentiation |
| morphogenesis of an epithelium |
| embryonic organ development |
| pattern specification process |
| negative regulation of immune system process |
| regulation of hemopoiesis |
| positive regulation of neurogenesis |
| muscle structure development |
| blood vessel development |
| vasculature development |
| regulation of lymphocyte activation |
| cardiovascular system development |
| heart development |
| positive regulation of nervous system development |
| positive regulation of cell development |
| sensory organ development |
| cell morphogenesis involved in differentiation |
| tissue morphogenesis |
| embryonic morphogenesis |
| regulation of leukocyte activation |
| hematopoietic or lymphoid organ development |
| regulation of mitotic cell cycle |
| chordate embryonic development |
| regulation of cell activation |
| immune system development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| regulation of neuron differentiation |
| neuron projection development |
| developmental process involved in reproduction |
| DNA-binding transcription factor activity |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| negative regulation of cell differentiation |
| cell morphogenesis |
| brain development |
| head development |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| tube development |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| protein homodimerization activity |
| positive regulation of cell population proliferation |
| regulation of nervous system development |
| cell adhesion |
| regulation of cell development |
| biological adhesion |
| negative regulation of developmental process |
| animal organ morphogenesis |
| cell migration |
| positive regulation of cell differentiation |
| embryo development |
| central nervous system development |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| localization of cell |
| cell motility |
| epithelium development |
| cell-cell signaling |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| cell projection organization |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| locomotion |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| protein-containing complex assembly |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| regulation of immune system process |
| positive regulation of signal transduction |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| BI-2536 0.0042μM R03 exp95 | 1.75 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 3/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 1/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15470
- Expression level (log2 read counts): -2.96
Expression Distribution
HES1 Expression in NALM6 Cells: -2.96
