HES3
Gene Information
- Official Symbol: HES3
- Official Name: hes family bHLH transcription factor 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 390992
- UniProt: Q5TGS1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Transcriptional repressor of genes that require a bHLH protein for their transcription. {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| HLH |
GO Terms
| trochlear nerve development |
| midbrain-hindbrain boundary morphogenesis |
| regulation of timing of neuron differentiation |
| oculomotor nerve development |
| midbrain-hindbrain boundary development |
| rostrocaudal neural tube patterning |
| regulation of timing of cell differentiation |
| regulation of development, heterochronic |
| preganglionic parasympathetic fiber development |
| parasympathetic nervous system development |
| neural tube patterning |
| hindbrain morphogenesis |
| autonomic nervous system development |
| cranial nerve development |
| nerve development |
| midbrain development |
| hindbrain development |
| protein dimerization activity |
| neural tube development |
| anterior/posterior pattern specification |
| DNA-binding transcription repressor activity, RNA polymerase II-specific |
| RNA polymerase II regulatory region sequence-specific DNA binding |
| regionalization |
| transcription factor binding |
| in utero embryonic development |
| pattern specification process |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| embryonic morphogenesis |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| regulation of neuron differentiation |
| brain development |
| head development |
| regulation of neurogenesis |
| tube development |
| negative regulation of transcription by RNA polymerase II |
| regulation of nervous system development |
| regulation of cell development |
| embryo development |
| central nervous system development |
| epithelium development |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| tissue development |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 1/5 |
Essentiality in NALM6
- Essentiality Rank: 16789
- Expression level (log2 read counts): -7.68
Expression Distribution
HES3 Expression in NALM6 Cells: -7.68
