HIST1H2BL

Entrez Summary: N/A
UniProt Summary: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bisphenol F 50μM R08 exp457	2.2

Gene	Correlation
HGC6.3	0.496

Global Fraction of Cell Lines Where Essential: 258/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	8/28
blood	18/28
bone	9/26
breast	12/33
central nervous system	17/56
cervix	2/4
colorectal	5/17
esophagus	4/13
fibroblast	1/1
gastric	5/16
kidney	6/21
liver	4/20
lung	15/75
lymphocyte	5/16
ovary	12/26
pancreas	7/24
peripheral nervous system	4/16
plasma cell	8/15
prostate	1/1
skin	7/24
soft tissue	2/9
thyroid	1/2
upper aerodigestive	5/22
urinary tract	15/29
uterus	2/5

Expression Distribution