HLA-DOB
Gene Information
- Official Symbol: HLA-DOB
- Official Name: major histocompatibility complex, class II, DO beta
- Aliases and Previous Symbols: N/A
- Entrez ID: 3112
- UniProt: P13765
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008].
- UniProt Summary: Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 10683
- Expression level (log2 read counts): 0.91
HLA-DOB Expression in NALM6 Cells: 0.91
