HPX
Gene Information
- Official Symbol: HPX
- Official Name: hemopexin
- Aliases and Previous Symbols: N/A
- Entrez ID: 3263
- UniProt: P02790
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.
Pfam Domains GO Terms
Pfam Domains
| Hemopexin |
GO Terms
| positive regulation of humoral immune response mediated by circulating immunoglobulin |
| positive regulation of interferon-gamma-mediated signaling pathway |
| positive regulation of response to interferon-gamma |
| heme transporter activity |
| heme transport |
| hemoglobin metabolic process |
| regulation of humoral immune response mediated by circulating immunoglobulin |
| iron coordination entity transport |
| endocytic vesicle lumen |
| positive regulation of humoral immune response |
| regulation of interferon-gamma-mediated signaling pathway |
| regulation of response to interferon-gamma |
| heme metabolic process |
| positive regulation of immunoglobulin mediated immune response |
| positive regulation of B cell mediated immunity |
| porphyrin-containing compound metabolic process |
| positive regulation of immunoglobulin production |
| cofactor transport |
| positive regulation of cytokine-mediated signaling pathway |
| regulation of immunoglobulin mediated immune response |
| regulation of B cell mediated immunity |
| positive regulation of response to cytokine stimulus |
| tetrapyrrole metabolic process |
| cellular iron ion homeostasis |
| pigment metabolic process |
| regulation of immunoglobulin production |
| positive regulation of tyrosine phosphorylation of STAT protein |
| iron ion transport |
| regulation of tyrosine phosphorylation of STAT protein |
| iron ion homeostasis |
| positive regulation of receptor signaling pathway via JAK-STAT |
| positive regulation of receptor signaling pathway via STAT |
| positive regulation of production of molecular mediator of immune response |
| positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| positive regulation of adaptive immune response |
| positive regulation of lymphocyte mediated immunity |
| cellular transition metal ion homeostasis |
| transition metal ion transport |
| regulation of receptor signaling pathway via JAK-STAT |
| transition metal ion homeostasis |
| positive regulation of leukocyte mediated immunity |
| regulation of receptor signaling pathway via STAT |
| regulation of humoral immune response |
| regulation of production of molecular mediator of immune response |
| blood microparticle |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| regulation of lymphocyte mediated immunity |
| regulation of adaptive immune response |
| regulation of cytokine-mediated signaling pathway |
| regulation of response to cytokine stimulus |
| positive regulation of peptidyl-tyrosine phosphorylation |
| regulation of leukocyte mediated immunity |
| positive regulation of immune effector process |
| receptor-mediated endocytosis |
| regulation of peptidyl-tyrosine phosphorylation |
| positive regulation of innate immune response |
| positive regulation of response to biotic stimulus |
| collagen-containing extracellular matrix |
| cofactor metabolic process |
| regulation of innate immune response |
| regulation of immune effector process |
| positive regulation of defense response |
| positive regulation of multi-organism process |
| regulation of response to biotic stimulus |
| endocytosis |
| cellular metal ion homeostasis |
| positive regulation of response to external stimulus |
| metal ion homeostasis |
| cellular cation homeostasis |
| metal ion transport |
| cellular ion homeostasis |
| import into cell |
| viral process |
| cation homeostasis |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| regulation of defense response |
| regulation of multi-organism process |
| symbiotic process |
| ion homeostasis |
| interspecies interaction between organisms |
| cation transport |
| positive regulation of immune response |
| cellular homeostasis |
| positive regulation of protein phosphorylation |
| positive regulation of phosphorylation |
| regulation of response to external stimulus |
| chemical homeostasis |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| positive regulation of immune system process |
| regulation of immune response |
| positive regulation of protein modification process |
| ion transport |
| regulation of protein phosphorylation |
| regulation of response to stress |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of immune system process |
| positive regulation of protein metabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of protein modification process |
| nitrogen compound transport |
| extracellular region |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8144
- Expression level (log2 read counts): -1.79
Expression Distribution
HPX Expression in NALM6 Cells: -1.79
