HS3ST3B1
Gene Information
- Official Symbol: HS3ST3B1
- Official Name: heparan sulfate-glucosamine 3-sulfotransferase 3B1
- Aliases and Previous Symbols: N/A
- Entrez ID: 9953
- UniProt: Q9Y662
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N- unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non- anticoagulant heparan sulfate to anticoagulant heparan sulfate. {ECO:0000269|PubMed:10520990}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 4852
- Expression level (log2 read counts): 4.8
HS3ST3B1 Expression in NALM6 Cells: 4.8
