Entrez Summary: This gene encodes a member of the heat shock factor (HSF) family of transcriptional activators for heat shock proteins. This gene is a candidate gene for azoospermia, since it localizes to a region of chromosome Y that is sometimes deleted in infertile males. The genome has two identical copies of this gene within a palindromic region; this record represents the more centromeric copy. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A
Pfam DomainsGO Terms
Pfam Domains
HSF DNA-bind
GO Terms
positive regulation of transcription from RNA polymerase II promoter in response to heat stress
positive regulation of transcription from RNA polymerase II promoter in response to stress
cellular response to heat
response to heat
regulation of transcription from RNA polymerase II promoter in response to stress
regulation of DNA-templated transcription in response to stress
response to temperature stimulus
sequence-specific DNA binding
RNA polymerase II proximal promoter sequence-specific DNA binding
DNA-binding transcription factor activity
response to abiotic stimulus
positive regulation of transcription by RNA polymerase II
positive regulation of transcription, DNA-templated