Entrez Summary: This gene encodes a small heat shock family B member that can heterodimerize with similar heat shock proteins. Defects in this gene are associated with advanced heart failure. In addition, the encoded protein may be a tumor suppressor in the p53 pathway, with defects in this gene being associated with renal cell carcinoma. [provided by RefSeq, Mar 2017].
UniProt Summary: N/A
Pfam DomainsGO Terms
Pfam Domains
HSP20
GO Terms
aggresome
Cajal body
response to unfolded protein
response to topologically incorrect protein
protein C-terminus binding
regulation of heart contraction
regulation of blood circulation
heart development
regulation of system process
circulatory system development
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739