HYAL2
Gene Information
- Official Symbol: HYAL2
- Official Name: hyaluronidase 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 8692
- UniProt: Q12891
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R. {ECO:0000269|PubMed:11296287, ECO:0000269|PubMed:12676986, ECO:0000269|PubMed:9712871}.
Pfam Domains GO Terms
Pfam Domains
| Glyco hydro 56 |
GO Terms
| receptor signaling protein tyrosine kinase inhibitor activity |
| hyaluronoglucuronidase activity |
| transformation of host cell by virus |
| renal water absorption |
| renal water transport |
| negative regulation of fibroblast migration |
| multi-organism membrane fusion |
| membrane fusion involved in viral entry into host cell |
| fusion of virus membrane with host plasma membrane |
| hyalurononglucosaminidase activity |
| cellular response to UV-B |
| monocyte activation |
| multicellular organismal iron ion homeostasis |
| multi-organism membrane organization |
| positive regulation of urine volume |
| renal absorption |
| positive regulation of interleukin-8 secretion |
| hyaluronan catabolic process |
| response to UV-B |
| anchored component of external side of plasma membrane |
| water transport |
| regulation of urine volume |
| transforming growth factor beta binding |
| multi-organism cellular process |
| hyaluronic acid binding |
| regulation of interleukin-8 secretion |
| fluid transport |
| negative regulation of protein tyrosine kinase activity |
| regulation of fibroblast migration |
| positive regulation of interleukin-6 secretion |
| hyaluronan metabolic process |
| modulation by virus of host morphology or physiology |
| anchored component of plasma membrane |
| multicellular organism aging |
| renal water homeostasis |
| positive regulation of protein import into nucleus |
| positive regulation of protein import |
| modification by symbiont of host morphology or physiology |
| negative regulation of protein kinase B signaling |
| positive regulation of extrinsic apoptotic signaling pathway |
| positive regulation of interleukin-8 production |
| negative regulation of peptidyl-tyrosine phosphorylation |
| regulation of protein import into nucleus |
| receptor tyrosine kinase binding |
| endocytic vesicle |
| regulation of protein import |
| glycosaminoglycan catabolic process |
| microvillus |
| positive regulation of nucleocytoplasmic transport |
| aminoglycan catabolic process |
| multicellular organismal water homeostasis |
| regulation of interleukin-8 production |
| RNA polymerase II transcription factor complex |
| water homeostasis |
| positive regulation of protein localization to nucleus |
| negative regulation of MAP kinase activity |
| virus receptor activity |
| iron ion homeostasis |
| cellular response to UV |
| hematopoietic progenitor cell differentiation |
| regulation of protein tyrosine kinase activity |
| viral entry into host cell |
| positive regulation of interleukin-6 production |
| entry into host |
| entry into host cell |
| regulation of nucleocytoplasmic transport |
| mucopolysaccharide metabolic process |
| cellular response to fibroblast growth factor stimulus |
| modification of morphology or physiology of other organism involved in symbiotic interaction |
| renal system process |
| cellular response to light stimulus |
| response to fibroblast growth factor |
| regulation of protein localization to nucleus |
| membrane fusion |
| transition metal ion homeostasis |
| negative regulation of protein serine/threonine kinase activity |
| positive regulation of cytokine secretion |
| positive regulation of inflammatory response |
| regulation of interleukin-6 production |
| response to UV |
| positive regulation of intracellular protein transport |
| regulation of extrinsic apoptotic signaling pathway |
| cellular response to transforming growth factor beta stimulus |
| modification of morphology or physiology of other organism |
| glycosaminoglycan metabolic process |
| interaction with host |
| response to transforming growth factor beta |
| aminoglycan metabolic process |
| negative regulation of MAPK cascade |
| cartilage development |
| positive regulation of apoptotic signaling pathway |
| cellular response to interleukin-1 |
| cellular response to radiation |
| negative regulation of cell growth |
| defense response to virus |
| carbohydrate derivative catabolic process |
| response to reactive oxygen species |
| response to interleukin-1 |
| viral life cycle |
| regulation of cytokine secretion |
| positive regulation of intracellular transport |
| regulation of protein kinase B signaling |
| connective tissue development |
| negative regulation of protein kinase activity |
| membrane raft |
| regulation of intracellular protein transport |
| skeletal system morphogenesis |
| cellular response to tumor necrosis factor |
| negative regulation of growth |
| negative regulation of kinase activity |
| lysosome |
| cytoplasmic vesicle |
| regulation of peptidyl-tyrosine phosphorylation |
| negative regulation of cell migration |
| response to tumor necrosis factor |
| organic acid catabolic process |
| carboxylic acid catabolic process |
| kidney development |
| positive regulation of protein secretion |
| negative regulation of cell motility |
| negative regulation of transferase activity |
| aging |
| response to virus |
| transcription coactivator activity |
| renal system development |
| positive regulation of peptide secretion |
| response to antibiotic |
| response to light stimulus |
| negative regulation of cellular component movement |
| cellular response to abiotic stimulus |
| cellular response to environmental stimulus |
| urogenital system development |
| apical plasma membrane |
| negative regulation of locomotion |
| multicellular organismal homeostasis |
| positive regulation of cellular protein localization |
| regulation of inflammatory response |
| regulation of MAP kinase activity |
| enzyme binding |
| regulation of intracellular transport |
| response to oxidative stress |
| regulation of apoptotic signaling pathway |
| positive regulation of secretion by cell |
| negative regulation of protein phosphorylation |
| regulation of cell growth |
| positive regulation of protein transport |
| positive regulation of secretion |
| small molecule catabolic process |
| response to radiation |
| negative regulation of phosphorylation |
| positive regulation of cytokine production |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| positive regulation of defense response |
| carbohydrate metabolic process |
| skeletal system development |
| regulation of peptide secretion |
| regulation of body fluid levels |
| cellular response to growth factor stimulus |
| negative regulation of intracellular signal transduction |
| regulation of protein serine/threonine kinase activity |
| response to growth factor |
| regulation of cellular protein localization |
| hemopoiesis |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| myeloid leukocyte activation |
| negative regulation of protein modification process |
| positive regulation of response to external stimulus |
| hematopoietic or lymphoid organ development |
| cell surface |
| Golgi membrane |
| metal ion homeostasis |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| immune system development |
| regulation of growth |
| regulation of cytokine production |
| perinuclear region of cytoplasm |
| positive regulation of cell death |
| viral process |
| regulation of protein transport |
| cation homeostasis |
| inorganic ion homeostasis |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| regulation of defense response |
| symbiotic process |
| ion homeostasis |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| regulation of secretion |
| interspecies interaction between organisms |
| regulation of cell migration |
| membrane organization |
| regulation of kinase activity |
| carboxylic acid metabolic process |
| regulation of cell motility |
| regulation of cellular localization |
| leukocyte activation |
| defense response to other organism |
| animal organ morphogenesis |
| regulation of transferase activity |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| oxoacid metabolic process |
| cellular response to cytokine stimulus |
| endoplasmic reticulum |
| organic acid metabolic process |
| regulation of protein localization |
| carbohydrate derivative metabolic process |
| negative regulation of cellular protein metabolic process |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| cell activation |
| immune effector process |
| regulation of response to external stimulus |
| response to cytokine |
| negative regulation of protein metabolic process |
| chemical homeostasis |
| negative regulation of molecular function |
| response to abiotic stimulus |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| negative regulation of signal transduction |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of response to stress |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of phosphorylation |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| tissue development |
| organic substance catabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12505
- Expression level (log2 read counts): 4.39
Expression Distribution
HYAL2 Expression in NALM6 Cells: 4.39
