IFI27
Gene Information
- Official Symbol: IFI27
- Official Name: interferon alpha inducible protein 27
- Aliases and Previous Symbols: N/A
- Entrez ID: 3429
- UniProt: P40305
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Promotes cell death. Mediates IFN-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9. {ECO:0000269|PubMed:18330707}.
Pfam Domains GO Terms
Pfam Domains
| Ifi-6-16 |
GO Terms
| modulation by host of viral genome replication |
| lamin binding |
| modulation by host of viral process |
| regulation of protein export from nucleus |
| nuclear inner membrane |
| RNA polymerase II activating transcription factor binding |
| protein K48-linked ubiquitination |
| cellular response to type I interferon |
| type I interferon signaling pathway |
| response to type I interferon |
| modification by host of symbiont morphology or physiology |
| interaction with symbiont |
| regulation of viral genome replication |
| extrinsic apoptotic signaling pathway |
| mitochondrial membrane |
| regulation of nucleocytoplasmic transport |
| modification of morphology or physiology of other organism involved in symbiotic interaction |
| regulation of viral life cycle |
| modification of morphology or physiology of other organism |
| mitochondrial outer membrane |
| nuclear envelope |
| defense response to virus |
| regulation of viral process |
| regulation of symbiosis, encompassing mutualism through parasitism |
| regulation of intracellular protein transport |
| response to virus |
| apoptotic signaling pathway |
| protein polyubiquitination |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| proteasomal protein catabolic process |
| regulation of intracellular transport |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| regulation of cellular protein localization |
| modification-dependent macromolecule catabolic process |
| proteolysis involved in cellular protein catabolic process |
| cellular protein catabolic process |
| cytokine-mediated signaling pathway |
| protein catabolic process |
| protein ubiquitination |
| viral process |
| regulation of protein transport |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| molecular function |
| innate immune response |
| protein modification by small protein conjugation |
| regulation of multi-organism process |
| symbiotic process |
| interspecies interaction between organisms |
| negative regulation of transcription by RNA polymerase II |
| cellular macromolecule catabolic process |
| regulation of cellular localization |
| apoptotic process |
| endoplasmic reticulum membrane |
| defense response to other organism |
| protein modification by small protein conjugation or removal |
| cellular response to cytokine stimulus |
| regulation of protein localization |
| macromolecule catabolic process |
| programmed cell death |
| organonitrogen compound catabolic process |
| identical protein binding |
| cell death |
| immune effector process |
| response to cytokine |
| negative regulation of transcription, DNA-templated |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| mitochondrion |
| proteolysis |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| negative regulation of RNA metabolic process |
| defense response |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| negative regulation of gene expression |
| organic substance catabolic process |
| cellular catabolic process |
| regulation of transport |
| immune response |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| THZ1 0.06μM R08 exp531 | 1.9 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13156
- Expression level (log2 read counts): 1.59
Expression Distribution
IFI27 Expression in NALM6 Cells: 1.59
