IFNB1
Gene Information
- Official Symbol: IFNB1
- Official Name: interferon beta 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 3456
- UniProt: P01574
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Has antiviral, antibacterial and anticancer activities.
Pfam Domains GO Terms
Pfam Domains
| Interferon |
GO Terms
| chloramphenicol O-acetyltransferase activity |
| negative regulation of T-helper 2 cell cytokine production |
| regulation of MHC class I biosynthetic process |
| negative regulation of T cell cytokine production |
| regulation of T-helper 2 cell cytokine production |
| negative regulation of type 2 immune response |
| type I interferon receptor binding |
| cellular response to exogenous dsRNA |
| negative regulation of T cell mediated immunity |
| positive regulation of peptidyl-serine phosphorylation of STAT protein |
| cellular response to interferon-beta |
| regulation of peptidyl-serine phosphorylation of STAT protein |
| cellular response to dsRNA |
| natural killer cell activation involved in immune response |
| negative regulation of cytokine production involved in immune response |
| response to interferon-beta |
| regulation of type 2 immune response |
| regulation of T cell cytokine production |
| negative regulation of production of molecular mediator of immune response |
| negative regulation of lymphocyte mediated immunity |
| negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| B cell proliferation |
| negative regulation of T cell differentiation |
| B cell activation involved in immune response |
| negative regulation of adaptive immune response |
| response to exogenous dsRNA |
| negative regulation of leukocyte mediated immunity |
| response to dsRNA |
| negative regulation of lymphocyte differentiation |
| natural killer cell activation |
| negative regulation of viral genome replication |
| T cell activation involved in immune response |
| cellular response to type I interferon |
| type I interferon signaling pathway |
| regulation of T cell mediated immunity |
| response to type I interferon |
| negative regulation of viral life cycle |
| lymphocyte proliferation |
| regulation of cytokine production involved in immune response |
| mononuclear cell proliferation |
| regulation of viral genome replication |
| negative regulation of viral process |
| leukocyte proliferation |
| negative regulation of leukocyte differentiation |
| positive regulation of peptidyl-serine phosphorylation |
| B cell differentiation |
| negative regulation of T cell activation |
| lymphocyte activation involved in immune response |
| negative regulation of immune effector process |
| negative regulation of leukocyte cell-cell adhesion |
| regulation of receptor signaling pathway via JAK-STAT |
| regulation of receptor signaling pathway via STAT |
| negative regulation of hemopoiesis |
| regulation of peptidyl-serine phosphorylation |
| regulation of T cell differentiation |
| regulation of production of molecular mediator of immune response |
| regulation of viral life cycle |
| negative regulation of lymphocyte activation |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| negative regulation of immune response |
| regulation of lymphocyte mediated immunity |
| B cell activation |
| regulation of adaptive immune response |
| regulation of lymphocyte differentiation |
| cytokine activity |
| negative regulation of leukocyte activation |
| positive regulation of apoptotic signaling pathway |
| negative regulation of cell-cell adhesion |
| defense response to virus |
| negative regulation of cell activation |
| regulation of leukocyte mediated immunity |
| regulation of viral process |
| negative regulation of multi-organism process |
| regulation of symbiosis, encompassing mutualism through parasitism |
| T cell activation |
| lymphocyte differentiation |
| negative regulation of cell adhesion |
| regulation of leukocyte differentiation |
| negative regulation of cytokine production |
| response to virus |
| blood coagulation |
| coagulation |
| regulation of leukocyte cell-cell adhesion |
| hemostasis |
| regulation of T cell activation |
| leukocyte differentiation |
| positive regulation of innate immune response |
| humoral immune response |
| positive regulation of response to biotic stimulus |
| lymphocyte activation |
| regulation of apoptotic signaling pathway |
| regulation of cell-cell adhesion |
| negative regulation of immune system process |
| regulation of hemopoiesis |
| regulation of innate immune response |
| regulation of immune effector process |
| positive regulation of defense response |
| wound healing |
| regulation of body fluid levels |
| positive regulation of multi-organism process |
| regulation of lymphocyte activation |
| regulation of response to biotic stimulus |
| cellular response to organic cyclic compound |
| cell population proliferation |
| hemopoiesis |
| response to wounding |
| positive regulation of response to external stimulus |
| regulation of leukocyte activation |
| hematopoietic or lymphoid organ development |
| adaptive immune response |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulation of cell activation |
| positive regulation of apoptotic process |
| immune system development |
| positive regulation of programmed cell death |
| cellular response to nitrogen compound |
| cytokine-mediated signaling pathway |
| regulation of cell adhesion |
| regulation of cytokine production |
| positive regulation of cell death |
| negative regulation of cell differentiation |
| regulation of defense response |
| innate immune response |
| regulation of multi-organism process |
| positive regulation of immune response |
| response to organic cyclic compound |
| leukocyte activation |
| negative regulation of developmental process |
| defense response to other organism |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of phosphorylation |
| cell activation |
| response to nitrogen compound |
| immune effector process |
| regulation of response to external stimulus |
| response to cytokine |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| regulation of immune response |
| positive regulation of immune system process |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| positive regulation of protein modification process |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| regulation of protein phosphorylation |
| regulation of response to stress |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of signal transduction |
| regulation of immune system process |
| regulation of cell death |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of protein modification process |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18593
- Expression level (log2 read counts): -7.68
Expression Distribution
IFNB1 Expression in NALM6 Cells: -7.68
