INSL3
Gene Information
- Official Symbol: INSL3
- Official Name: insulin like 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 3640
- UniProt: P51460
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the insulin-like hormone superfamily. The encoded protein is mainly produced in gonadal tissues. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. This protein may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. Mutations in this gene may lead to cryptorchidism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012].
- UniProt Summary: Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 8884
- Expression level (log2 read counts): -0.67
INSL3 Expression in NALM6 Cells: -0.67
