IQSEC2
Gene Information
- Official Symbol: IQSEC2
- Official Name: IQ motif and Sec7 domain ArfGEF 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 23096
- UniProt: Q5JU85
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a guanine nucleotide exchange factor for the ARF family of small GTP-binding proteins. The encoded protein is a component of the postsynaptic density at excitatory synapses, and may play a critical role in cytoskeletal and synaptic organization through the activation of selected ARF substrates including ARF1 and ARF6. Mutations in this gene have been implicated in nonsyndromic X-linked cognitive disability. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011].
- UniProt Summary: Is a guanine nucleotide exchange factor for the ARF GTP- binding proteins. {ECO:0000269|PubMed:26793055}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 6303
- Expression level (log2 read counts): -0.46
IQSEC2 Expression in NALM6 Cells: -0.46
