IRX2
Gene Information
- Official Symbol: IRX2
- Official Name: iroquois homeobox 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 153572
- UniProt: Q9BZI1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Homeobox |
| Homeobox KN |
GO Terms
| proximal/distal pattern formation involved in metanephric nephron development |
| pattern specification involved in metanephros development |
| specification of loop of Henle identity |
| specification of nephron tubule identity |
| proximal/distal pattern formation involved in nephron development |
| renal system pattern specification |
| pattern specification involved in kidney development |
| loop of Henle development |
| nephron tubule formation |
| segment specification |
| proximal/distal pattern formation |
| metanephric nephron development |
| nephron tubule morphogenesis |
| nephron epithelium morphogenesis |
| nephron morphogenesis |
| renal tubule morphogenesis |
| nephron tubule development |
| renal tubule development |
| metanephros development |
| kidney morphogenesis |
| segmentation |
| nephron epithelium development |
| embryonic epithelial tube formation |
| nephron development |
| kidney epithelium development |
| epithelial tube formation |
| morphogenesis of embryonic epithelium |
| tube formation |
| DNA-binding transcription repressor activity, RNA polymerase II-specific |
| kidney development |
| renal system development |
| epithelial tube morphogenesis |
| urogenital system development |
| regionalization |
| sequence-specific DNA binding |
| morphogenesis of an epithelium |
| pattern specification process |
| tissue morphogenesis |
| embryonic morphogenesis |
| tube morphogenesis |
| tube development |
| negative regulation of transcription by RNA polymerase II |
| anatomical structure formation involved in morphogenesis |
| animal organ morphogenesis |
| embryo development |
| epithelium development |
| negative regulation of transcription, DNA-templated |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| negative regulation of gene expression |
| tissue development |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| ABT-702 5μM plus CoCl2 18μM R07 exp320 | -1.8 |
| PFI-2 4μM R05 exp239 | 1.88 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3604
- Expression level (log2 read counts): -0.94
Expression Distribution
IRX2 Expression in NALM6 Cells: -0.94
