ITGB5
Gene Information
- Official Symbol: ITGB5
- Official Name: integrin subunit beta 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 3693
- UniProt: P18084
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.
Pfam Domains GO Terms
Pfam Domains
| Integrin b cyt |
| Integrin beta |
| Integrin B tail |
GO Terms
| integrin alphav-beta5 complex |
| epithelial cell-cell adhesion |
| contractile actin filament bundle assembly |
| stress fiber assembly |
| cell adhesion mediated by integrin |
| integrin complex |
| endodermal cell differentiation |
| endoderm formation |
| phagocytic vesicle |
| actin filament bundle assembly |
| actin filament bundle organization |
| endoderm development |
| antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
| virus receptor activity |
| antigen processing and presentation of exogenous peptide antigen via MHC class I |
| integrin-mediated signaling pathway |
| viral entry into host cell |
| antigen processing and presentation of peptide antigen via MHC class I |
| entry into host cell |
| transforming growth factor beta receptor signaling pathway |
| entry into host |
| formation of primary germ layer |
| actomyosin structure organization |
| cell-matrix adhesion |
| integrin binding |
| cellular response to transforming growth factor beta stimulus |
| interaction with host |
| gastrulation |
| response to transforming growth factor beta |
| antigen processing and presentation of exogenous peptide antigen |
| antigen processing and presentation of exogenous antigen |
| cell-substrate adhesion |
| antigen processing and presentation of peptide antigen |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| viral life cycle |
| signaling receptor activity |
| receptor complex |
| antigen processing and presentation |
| actin filament organization |
| muscle contraction |
| muscle system process |
| extracellular matrix organization |
| extracellular structure organization |
| focal adhesion |
| supramolecular fiber organization |
| actin cytoskeleton organization |
| cellular response to growth factor stimulus |
| cell-cell adhesion |
| response to growth factor |
| embryonic morphogenesis |
| actin filament-based process |
| cell surface |
| viral process |
| enzyme linked receptor protein signaling pathway |
| symbiotic process |
| interspecies interaction between organisms |
| anatomical structure formation involved in morphogenesis |
| cell adhesion |
| biological adhesion |
| cell migration |
| embryo development |
| localization of cell |
| cell motility |
| cytoskeleton organization |
| cellular response to endogenous stimulus |
| locomotion |
| response to endogenous stimulus |
| movement of cell or subcellular component |
| tissue development |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 30/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 3/28 |
| blood | 0/28 |
| bone | 2/26 |
| breast | 3/33 |
| central nervous system | 6/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 1/21 |
| liver | 2/20 |
| lung | 2/75 |
| lymphocyte | 0/16 |
| ovary | 1/26 |
| pancreas | 2/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 2/29 |
| uterus | 1/5 |
Essentiality in NALM6
- Essentiality Rank: 4896
- Expression level (log2 read counts): -0.44
Expression Distribution
ITGB5 Expression in NALM6 Cells: -0.44
