KCNH2
Gene Information
- Official Symbol: KCNH2
- Official Name: potassium voltage-gated channel subfamily H member 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 3757
- UniProt: Q12809
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Ion trans |
| cNMP binding |
| Ion trans 2 |
| PAS |
GO Terms
| regulation of heart rate by hormone |
| negative regulation of potassium ion export across plasma membrane |
| inward rectifier potassium channel complex |
| regulation of heart rate by chemical signal |
| C3HC4-type RING finger domain binding |
| regulation of potassium ion export across plasma membrane |
| voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization |
| membrane repolarization during ventricular cardiac muscle cell action potential |
| voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization |
| ventricular cardiac muscle cell membrane repolarization |
| potassium ion export across plasma membrane |
| cardiac muscle cell membrane repolarization |
| membrane repolarization during cardiac muscle cell action potential |
| membrane repolarization during action potential |
| inward rectifier potassium channel activity |
| ventricular cardiac muscle cell action potential |
| membrane repolarization |
| regulation of ventricular cardiac muscle cell membrane repolarization |
| negative regulation of potassium ion transmembrane transport |
| regulation of cardiac muscle cell membrane repolarization |
| potassium ion homeostasis |
| membrane depolarization during action potential |
| negative regulation of potassium ion transport |
| delayed rectifier potassium channel activity |
| regulation of membrane repolarization |
| positive regulation of potassium ion transmembrane transport |
| regulation of heart rate by cardiac conduction |
| export across plasma membrane |
| cardiac muscle cell action potential involved in contraction |
| cardiac muscle cell contraction |
| potassium ion import across plasma membrane |
| positive regulation of potassium ion transport |
| cardiac muscle cell action potential |
| membrane depolarization |
| scaffold protein binding |
| voltage-gated potassium channel activity |
| inorganic ion import across plasma membrane |
| inorganic cation import across plasma membrane |
| cardiac muscle contraction |
| regulation of potassium ion transmembrane transport |
| negative regulation of cation transmembrane transport |
| voltage-gated potassium channel complex |
| heart contraction |
| actin-mediated cell contraction |
| cardiac conduction |
| action potential |
| negative regulation of ion transmembrane transport |
| regulation of potassium ion transport |
| regulation of heart rate |
| import across plasma membrane |
| heart process |
| striated muscle contraction |
| actin filament-based movement |
| negative regulation of transmembrane transport |
| multicellular organismal signaling |
| monovalent inorganic cation homeostasis |
| positive regulation of cation transmembrane transport |
| negative regulation of ion transport |
| positive regulation of ion transmembrane transport |
| potassium ion transmembrane transport |
| potassium ion transport |
| positive regulation of transmembrane transport |
| regulation of heart contraction |
| muscle contraction |
| positive regulation of ion transport |
| regulation of blood circulation |
| ubiquitin protein ligase binding |
| muscle system process |
| regulation of cation transmembrane transport |
| regulation of metal ion transport |
| blood circulation |
| circulatory system process |
| monovalent inorganic cation transport |
| cellular response to drug |
| regulation of membrane potential |
| regulation of ion transmembrane transport |
| negative regulation of transport |
| inorganic cation transmembrane transport |
| regulation of transmembrane transport |
| actin filament-based process |
| regulation of system process |
| cation transmembrane transport |
| cell surface |
| metal ion homeostasis |
| metal ion transport |
| inorganic ion transmembrane transport |
| import into cell |
| perinuclear region of cytoplasm |
| regulation of ion transport |
| cation homeostasis |
| inorganic ion homeostasis |
| ion homeostasis |
| cation transport |
| protein homodimerization activity |
| ion transmembrane transport |
| positive regulation of transport |
| response to drug |
| export from cell |
| identical protein binding |
| chemical homeostasis |
| transmembrane transport |
| ion transport |
| integral component of plasma membrane |
| movement of cell or subcellular component |
| homeostatic process |
| regulation of transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5027
- Expression level (log2 read counts): -4.6
Expression Distribution
KCNH2 Expression in NALM6 Cells: -4.6
