Entrez Summary: This gene encodes a member of voltage-gated potassium channels. Members of this family have diverse functions, including regulating neurotransmitter and hormone release, cardiac function, and cell volume. This protein is an outward-rectifying, noninactivating channel. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
UniProt Summary: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly.
Pfam DomainsGO Terms
Pfam Domains
Ion trans 2
cNMP binding
Ion trans
PAS
GO Terms
voltage-gated potassium channel activity
ion channel binding
potassium ion transmembrane transport
potassium ion transport
regulation of G2/M transition of mitotic cell cycle
calmodulin binding
regulation of cell cycle G2/M phase transition
monovalent inorganic cation transport
regulation of mitotic cell cycle phase transition
regulation of membrane potential
regulation of cell cycle phase transition
regulation of ion transmembrane transport
protein heterodimerization activity
inorganic cation transmembrane transport
regulation of transmembrane transport
cation transmembrane transport
cell surface
regulation of mitotic cell cycle
metal ion transport
inorganic ion transmembrane transport
regulation of ion transport
regulation of cell cycle process
cation transport
ion transmembrane transport
regulation of cell cycle
transmembrane transport
ion transport
integral component of plasma membrane
regulation of transport
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)