Entrez Summary: This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009].
UniProt Summary: N/A
Pfam DomainsGO Terms
Pfam Domains
KCNQ channel
Ion trans 2
Ion trans
GO Terms
clathrin coat
delayed rectifier potassium channel activity
voltage-gated potassium channel activity
voltage-gated potassium channel complex
potassium ion transmembrane transport
potassium ion transport
calmodulin binding
monovalent inorganic cation transport
regulation of ion transmembrane transport
inorganic cation transmembrane transport
regulation of transmembrane transport
cation transmembrane transport
metal ion transport
inorganic ion transmembrane transport
regulation of ion transport
cation transport
ion transmembrane transport
transmembrane transport
ion transport
integral component of plasma membrane
regulation of transport
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)