UniProt Summary: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. {ECO:0000305}.
Pfam DomainsGO Terms
Pfam Domains
K tetra
DUF3354
Pentapeptide
GO Terms
cullin family protein binding
protein self-association
protein homooligomerization
protein complex oligomerization
protein ubiquitination
protein modification by small protein conjugation
protein modification by small protein conjugation or removal
identical protein binding
protein-containing complex assembly
intracellular signal transduction
protein-containing complex subunit organization
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739