UniProt Summary: May modifie wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9. {ECO:0000269|PubMed:23381944}.
Pfam DomainsGO Terms
Pfam Domains
Methyltransf 12
Ubie methyltran
Methyltransf 8
Methyltransf 11
GO Terms
tRNA (uracil) methyltransferase activity
tRNA methyltransferase activity
2-oxoglutarate-dependent dioxygenase activity
tRNA wobble uridine modification
tRNA wobble base modification
tRNA methylation
tRNA binding
RNA methylation
tRNA modification
tRNA processing
RNA modification
tRNA metabolic process
macromolecule methylation
methylation
ncRNA processing
ncRNA metabolic process
RNA processing
oxidation-reduction process
RNA metabolic process
gene expression
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739