KRT20
Gene Information
- Official Symbol: KRT20
- Official Name: keratin 20
- Aliases and Previous Symbols: N/A
- Entrez ID: 54474
- UniProt: P35900
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008].
- UniProt Summary: Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity). {ECO:0000250, ECO:0000269|PubMed:12857878, ECO:0000269|PubMed:16608857}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 7267
- Expression level (log2 read counts): -5.6
KRT20 Expression in NALM6 Cells: -5.6
