KRTAP4-12

Entrez Summary: N/A
UniProt Summary: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Calcium Ionophore 0.4μM R07 exp342	-2.63
Erlotinib 10μM R05 exp216	-1.88
CoCl2 18μM R07 exp346	-1.84
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-1.77
UM0131023 0.05μM R05 exp248	-1.74
Tubacin 1.6μM R07 exp416	-1.72
GSK343 3μM R03 exp124	1.74
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	1.8
Trimetrexate 0.03μM R08 exp535	1.97

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution