UniProt Summary: Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release. {ECO:0000269|PubMed:11706006}.
Pfam DomainsGO Terms
Pfam Domains
Gal-bind lectin
GO Terms
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
carbohydrate binding
cell-cell adhesion via plasma-membrane adhesion molecules
cell-cell adhesion
apoptotic process
cell adhesion
biological adhesion
programmed cell death
cell death
extracellular space
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739