LHFPL5
Gene Information
- Official Symbol: LHFPL5
- Official Name: LHFPL tetraspan subfamily member 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 222662
- UniProt: Q8TAF8
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. Mutations in this gene result in deafness in humans, and a mutation in a similar gene in mice results in deafness and vestibular dysfunction with severe degeneration of the organ of Corti. It is proposed to function in hair bundle morphogenesis. [provided by RefSeq, Jul 2008].
- UniProt Summary: In the inner ear, may be a component of the hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel. Regulates transducer channel conductance and is required for fast channel adaptation (By similarity). {ECO:0000250}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 10197
- Expression level (log2 read counts): 3.86
LHFPL5 Expression in NALM6 Cells: 3.86
