LHX2
Gene Information
- Official Symbol: LHX2
- Official Name: LIM homeobox 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 9355
- UniProt: P50458
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity). {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| LIM |
| Homeobox |
GO Terms
| maintenance of apical/basal cell polarity |
| maintenance of epithelial cell apical/basal polarity |
| telencephalon regionalization |
| maintenance of cell polarity |
| negative regulation of transcription regulatory region DNA binding |
| forebrain regionalization |
| olfactory bulb development |
| olfactory lobe development |
| axon extension |
| establishment or maintenance of epithelial cell apical/basal polarity |
| establishment or maintenance of bipolar cell polarity |
| establishment or maintenance of apical/basal cell polarity |
| regulation of transcription regulatory region DNA binding |
| positive regulation of neural precursor cell proliferation |
| negative regulation of DNA binding |
| neuron projection extension |
| hair follicle development |
| skin epidermis development |
| molting cycle process |
| hair cycle process |
| dorsal/ventral pattern formation |
| negative regulation of gene expression, epigenetic |
| regulation of neural precursor cell proliferation |
| developmental cell growth |
| cell growth |
| neural tube closure |
| tube closure |
| hair cycle |
| molting cycle |
| primary neural tube formation |
| neural tube formation |
| developmental growth involved in morphogenesis |
| cerebral cortex development |
| embryonic epithelial tube formation |
| mesoderm development |
| regulation of DNA binding |
| epithelial tube formation |
| retina development in camera-type eye |
| morphogenesis of embryonic epithelium |
| tube formation |
| neural tube development |
| negative regulation of binding |
| pallium development |
| establishment or maintenance of cell polarity |
| regulation of gene expression, epigenetic |
| telencephalon development |
| axon guidance |
| neuron projection guidance |
| negative regulation of neurogenesis |
| epithelial tube morphogenesis |
| negative regulation of nervous system development |
| RNA polymerase II regulatory region sequence-specific DNA binding |
| camera-type eye development |
| regionalization |
| transcription factor binding |
| negative regulation of cell development |
| eye development |
| visual system development |
| sensory system development |
| axonogenesis |
| regulation of binding |
| skin development |
| forebrain development |
| developmental growth |
| growth |
| chromatin binding |
| axon development |
| epidermis development |
| cell morphogenesis involved in neuron differentiation |
| morphogenesis of an epithelium |
| pattern specification process |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| cell part morphogenesis |
| sensory organ development |
| chemotaxis |
| taxis |
| cell morphogenesis involved in differentiation |
| tissue morphogenesis |
| embryonic morphogenesis |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| neuron projection development |
| negative regulation of cell differentiation |
| cell morphogenesis |
| brain development |
| head development |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| tube development |
| anatomical structure formation involved in morphogenesis |
| positive regulation of cell population proliferation |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| embryo development |
| central nervous system development |
| neuron differentiation |
| epithelium development |
| plasma membrane bounded cell projection organization |
| negative regulation of molecular function |
| cell projection organization |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| locomotion |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| movement of cell or subcellular component |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of cell population proliferation |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| tissue development |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13474
- Expression level (log2 read counts): -1.45
Expression Distribution
LHX2 Expression in NALM6 Cells: -1.45
