LSM14A
Gene Information
- Official Symbol: LSM14A
- Official Name: LSM14A mRNA processing body assembly factor
- Aliases and Previous Symbols: N/A
- Entrez ID: 26065
- UniProt: Q8ND56
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs. {ECO:0000269|PubMed:16484376, ECO:0000269|PubMed:17074753}.
Pfam Domains GO Terms
Pfam Domains
| FFD TFG |
| DFDF |
| LSM14 |
GO Terms
| RIG-I signaling pathway |
| cytoplasmic pattern recognition receptor signaling pathway in response to virus |
| cytoplasmic mRNA processing body assembly |
| positive regulation of type I interferon-mediated signaling pathway |
| multi-organism cellular process |
| cellular response to virus |
| regulation of type I interferon-mediated signaling pathway |
| cytoplasmic pattern recognition receptor signaling pathway |
| single-stranded RNA binding |
| positive regulation of cytokine-mediated signaling pathway |
| positive regulation of response to cytokine stimulus |
| cytoplasmic stress granule |
| cytoplasmic ribonucleoprotein granule |
| double-stranded RNA binding |
| P-body |
| double-stranded DNA binding |
| pattern recognition receptor signaling pathway |
| regulation of cytokine-mediated signaling pathway |
| intracellular receptor signaling pathway |
| regulation of response to cytokine stimulus |
| defense response to virus |
| ribonucleoprotein complex assembly |
| innate immune response-activating signal transduction |
| ribonucleoprotein complex subunit organization |
| activation of innate immune response |
| response to virus |
| positive regulation of innate immune response |
| regulation of translation |
| positive regulation of response to biotic stimulus |
| regulation of cellular amide metabolic process |
| positive regulation of cytokine production |
| regulation of innate immune response |
| ribonucleoprotein complex biogenesis |
| positive regulation of defense response |
| positive regulation of multi-organism process |
| regulation of response to biotic stimulus |
| posttranscriptional regulation of gene expression |
| immune response-activating signal transduction |
| immune response-regulating signaling pathway |
| positive regulation of response to external stimulus |
| activation of immune response |
| regulation of cytokine production |
| organelle assembly |
| regulation of defense response |
| regulation of multi-organism process |
| cellular protein-containing complex assembly |
| positive regulation of immune response |
| defense response to other organism |
| immune effector process |
| regulation of response to external stimulus |
| positive regulation of immune system process |
| regulation of immune response |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| RNA binding |
| regulation of response to stress |
| protein-containing complex assembly |
| regulation of immune system process |
| positive regulation of signal transduction |
| intracellular signal transduction |
| positive regulation of multicellular organismal process |
| positive regulation of cell communication |
| positive regulation of signaling |
| protein-containing complex subunit organization |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13668
- Expression level (log2 read counts): 7.26
Expression Distribution
LSM14A Expression in NALM6 Cells: 7.26
