MEIOB
Gene Information
- Official Symbol: MEIOB
- Official Name: meiosis specific with OB-fold
- Aliases and Previous Symbols: N/A
- Entrez ID: 254528
- UniProt: Q8N635
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity in vitro (By similarity). {ECO:0000250}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 17792
- Expression level (log2 read counts): -2.9
MEIOB Expression in NALM6 Cells: -2.9
