UniProt Summary: Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE- mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (By similarity). {ECO:0000250}.
Pfam DomainsGO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
negative regulation of mast cell activation
mast cell activation involved in immune response
mast cell degranulation
mast cell mediated immunity
mast cell granule
mast cell activation
lysosome localization
regulation of mast cell activation
negative regulation of leukocyte activation
negative regulation of cell activation
establishment of organelle localization
negative regulation of immune system process
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
organelle localization
myeloid leukocyte activation
regulation of leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
regulation of cell activation
regulated exocytosis
leukocyte mediated immunity
exocytosis
leukocyte activation
secretion by cell
export from cell
cell activation
immune effector process
secretion
integral component of plasma membrane
intracellular transport
regulation of immune system process
establishment of localization in cell
immune response
vesicle-mediated transport
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)