MMD2
Gene Information
- Official Symbol: MMD2
- Official Name: monocyte to macrophage differentiation associated 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 221938
- UniProt: Q8IY49
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| HlyIII |
GO Terms
| positive regulation of Ras protein signal transduction |
| positive regulation of small GTPase mediated signal transduction |
| protein kinase activity |
| regulation of Ras protein signal transduction |
| regulation of small GTPase mediated signal transduction |
| positive regulation of neuron differentiation |
| positive regulation of neurogenesis |
| positive regulation of protein kinase activity |
| positive regulation of nervous system development |
| positive regulation of cell development |
| positive regulation of kinase activity |
| Golgi membrane |
| regulation of neuron differentiation |
| positive regulation of transferase activity |
| perinuclear region of cytoplasm |
| regulation of protein kinase activity |
| regulation of neurogenesis |
| regulation of kinase activity |
| regulation of nervous system development |
| regulation of cell development |
| positive regulation of cell differentiation |
| protein phosphorylation |
| regulation of transferase activity |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| positive regulation of phosphorylation |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of protein modification process |
| phosphorylation |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| generation of neurons |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| neurogenesis |
| positive regulation of signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Taxol 0.004μM R03 exp103 | -1.7 |
| DABN racemic mixture R03 exp93 | 1.88 |
| Nocodazole 0.1μM R03 exp94 | 2.07 |
| Nocodazole 0.2μM R02 exp64 | 2.42 |
| SB743921 0.001μM R05 exp244 | 2.54 |
| Vinblastine 0.015μM R05 exp208 | 2.67 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15012
- Expression level (log2 read counts): -4.6
Expression Distribution
MMD2 Expression in NALM6 Cells: -4.6
