MMP17
Gene Information
- Official Symbol: MMP17
- Official Name: matrix metallopeptidase 17
- Aliases and Previous Symbols: N/A
- Entrez ID: 4326
- UniProt: Q9ULZ9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Cleaves pro-TNF-alpha at the '74-Ala-|-Gln-75' site. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1- antitrypsin.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 2937
- Expression level (log2 read counts): -1.82
MMP17 Expression in NALM6 Cells: -1.82
