MOS
Gene Information
- Official Symbol: MOS
- Official Name: MOS proto-oncogene, serine/threonine kinase
- Aliases and Previous Symbols: N/A
- Entrez ID: 4342
- UniProt: P00540
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Pkinase Tyr |
| Pkinase |
GO Terms
| establishment of meiotic spindle orientation |
| negative regulation of metaphase/anaphase transition of meiotic cell cycle |
| negative regulation of meiotic chromosome separation |
| negative regulation of meiotic cell cycle phase transition |
| regulation of metaphase/anaphase transition of meiotic cell cycle |
| regulation of meiotic chromosome separation |
| establishment of meiotic spindle localization |
| regulation of meiotic cell cycle phase transition |
| negative regulation of meiotic nuclear division |
| meiotic spindle organization |
| negative regulation of meiotic cell cycle |
| MAP kinase kinase kinase activity |
| negative regulation of metaphase/anaphase transition of cell cycle |
| negative regulation of chromosome separation |
| regulation of meiotic nuclear division |
| negative regulation of chromosome segregation |
| establishment of spindle orientation |
| establishment of spindle localization |
| spindle localization |
| negative regulation of nuclear division |
| regulation of meiotic cell cycle |
| regulation of metaphase/anaphase transition of cell cycle |
| activation of MAPKK activity |
| negative regulation of reproductive process |
| regulation of chromosome separation |
| regulation of sister chromatid segregation |
| regulation of chromosome segregation |
| establishment of cell polarity |
| spindle organization |
| activation of MAPK activity |
| regulation of reproductive process |
| meiotic cell cycle process |
| regulation of nuclear division |
| protein autophosphorylation |
| establishment or maintenance of cell polarity |
| meiotic cell cycle |
| negative regulation of cell cycle phase transition |
| positive regulation of MAP kinase activity |
| negative regulation of cell cycle process |
| activation of protein kinase activity |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| regulation of chromosome organization |
| establishment of organelle localization |
| protein serine/threonine kinase activity |
| MAPK cascade |
| negative regulation of organelle organization |
| signal transduction by protein phosphorylation |
| regulation of cell cycle phase transition |
| microtubule cytoskeleton organization |
| regulation of protein serine/threonine kinase activity |
| positive regulation of protein kinase activity |
| positive regulation of MAPK cascade |
| negative regulation of cell cycle |
| positive regulation of kinase activity |
| organelle localization |
| positive regulation of transferase activity |
| microtubule-based process |
| chromatin organization |
| negative regulation of cellular component organization |
| regulation of cell cycle process |
| regulation of MAPK cascade |
| regulation of protein kinase activity |
| regulation of kinase activity |
| protein phosphorylation |
| regulation of transferase activity |
| cell cycle process |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| positive regulation of phosphorylation |
| chromosome organization |
| cytoskeleton organization |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| regulation of cell cycle |
| positive regulation of protein modification process |
| phosphorylation |
| regulation of organelle organization |
| cell cycle |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| ATP binding |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| positive regulation of signal transduction |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| PFI-2 4μM R05 exp239 | 1.7 |
| Taxol 0.004μM R03 exp103 | 1.87 |
| Geldanamycin 0.01μM R05 exp235 | 1.97 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4360
- Expression level (log2 read counts): -7.68
Expression Distribution
MOS Expression in NALM6 Cells: -7.68
