Entrez Summary: The protein encoded by this gene has multiple PDZ domains, which are hallmarks of protein-protein interactions. The encoded protein is known to interact with the HTR2C receptor and may cause it to clump at the cell surface. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015].
UniProt Summary: N/A
Pfam DomainsGO Terms
Pfam Domains
L27 2
PDZ
GO Terms
Schmidt-Lanterman incisure
apicolateral plasma membrane
bicellular tight junction
protein C-terminus binding
postsynaptic membrane
postsynaptic density
cytoplasmic vesicle
apical plasma membrane
dendrite
viral process
symbiotic process
interspecies interaction between organisms
cell adhesion
biological adhesion
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739